Heart failure with preserved ejection fraction: Insights from recent clinical researches

Mi Na Kim, Seong Mi Park

Research output: Contribution to journalReview article

Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor prognosis as well as frequent hospitalization and increased mortality compared with HF with reduced ejection fraction. The concept of HFpEF is still evolving and may be a virtual complex rather than a real systemic disorder. Thus, beyond solely targeting cardiac abnormalities management strategies need to be extended, such as left ventricular diastolic dysfunction. In this review, we examine new diagnostic algorithms, pathophysiology, current management status, and ongoing trials based on heterogeneous pathophysiology and etiology in HFpEF.

Original languageEnglish
Pages (from-to)514-534
Number of pages21
JournalKorean Journal of Internal Medicine
Volume35
Issue number3
DOIs
Publication statusPublished - 2020 May

Keywords

  • Heart failure
  • Preserved ejection fraction
  • Therapy

ASJC Scopus subject areas

  • Internal Medicine

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