Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

Jeong Bae Park, Ja Seol Koo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Gastrointestinal lymphoma is the most common type of extranodal lymphoma, and most commonly affects the stomach. Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and diffuse large B-cell lymphoma are the most common histologic types of gastric lymphoma. Despite its increasing incidence, diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings, and, thus, a high index of suspicion, and multiple, deep, repeated biopsies at abnormally and normally appearing sites in the stomach are needed. In addition, testing for Helicobacter pylori (H. pylori) infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to H. pylori eradication and for assessment of disease progression. In addition, H. pylori infection and MALT lymphoma development are associated, and complete regression of low-grade MALT lymphomas after H. pylori eradication has been demonstrated. Radiotherapy and/or chemotherapy can be used in cases that show poor response to H. pylori eradication, negativity for H. pylori infection, or high-grade lymphoma.

Original languageEnglish
Pages (from-to)2751-2759
Number of pages9
JournalWorld Journal of Gastroenterology
Volume20
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

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Marginal Zone B-Cell Lymphoma
Helicobacter Infections
Gastric Mucosa
Helicobacter pylori
Non-Hodgkin's Lymphoma
Lymphoma
Stomach
Endosonography
Lymphoma, Large B-Cell, Diffuse
Disease Progression
Radiotherapy
Lymph Nodes
Biopsy
Drug Therapy
Incidence
Neoplasms

Keywords

  • Eradication
  • Helicobacter pylori
  • Lymphoma
  • Mucosa-associated lymphoid tissue
  • Remission

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma. / Park, Jeong Bae; Koo, Ja Seol.

In: World Journal of Gastroenterology, Vol. 20, No. 11, 01.01.2014, p. 2751-2759.

Research output: Contribution to journalArticle

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