Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

Jeong Bae Park, Ja Seol Koo

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Gastrointestinal lymphoma is the most common type of extranodal lymphoma, and most commonly affects the stomach. Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and diffuse large B-cell lymphoma are the most common histologic types of gastric lymphoma. Despite its increasing incidence, diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings, and, thus, a high index of suspicion, and multiple, deep, repeated biopsies at abnormally and normally appearing sites in the stomach are needed. In addition, testing for Helicobacter pylori (H. pylori) infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to H. pylori eradication and for assessment of disease progression. In addition, H. pylori infection and MALT lymphoma development are associated, and complete regression of low-grade MALT lymphomas after H. pylori eradication has been demonstrated. Radiotherapy and/or chemotherapy can be used in cases that show poor response to H. pylori eradication, negativity for H. pylori infection, or high-grade lymphoma.

    Original languageEnglish
    Pages (from-to)2751-2759
    Number of pages9
    JournalWorld journal of gastroenterology
    Issue number11
    Publication statusPublished - 2014 Mar


    • Eradication
    • Helicobacter pylori
    • Lymphoma
    • Mucosa-associated lymphoid tissue
    • Remission

    ASJC Scopus subject areas

    • Gastroenterology


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