Hemagglutination inhibiting antibody persistence 1 year after influenza vaccination in Korean children and adolescents

Eun Kyeong Kang, Byung Wook Eun, Nam Hee Kim, Yun Kyung Kim, Jung Sub Lim, Dong Ho Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study aimed to assess the 1-y immunogenicity of influenza vaccines and the association between immunogenicity at 1 m and further influenza infections in children aged 6 m to 18 y. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 m post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91.2%, 87.6%, and 87.6%, respectively, at 1 month (n = 174). These rates were 76.5%, 64.7%, and 54.6%, respectively, at 12 m. The seroprotection rates and GMTs for influenza A(H1N1) and A(H3N2) were higher at 12 m than at 0 m (p < 0.05) but not for B. There were 39 subjects (42 cases) of serological influenza infections. Subjects with seroprotection at 1 m post-vaccination had showed fewer serologic A(H1N1) (10.1 vs 54.5%) and A(H3N2) (7.2 vs 38.1%) infections than the ones with HI titer <1:40 during follow-up (P < 0.01). In conclusion, influenza vaccines used during the 2008-09 season induced adequate 1-y immunogenicity for A(H1N1) and A(H3N2). The immunogenicity at one month after vaccination influenced further serological influenza infections.

Original languageEnglish
Pages (from-to)895-902
Number of pages8
JournalHuman Vaccines and Immunotherapeutics
Volume13
Issue number4
DOIs
Publication statusPublished - 2017 Apr 3

Keywords

  • 1-year immunogenicity
  • children
  • hemagglutination inhibition
  • influenza vaccine
  • seroprotection rate

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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