Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

Sunila Pradeep, SeungW Kim, SherryY Wu, Masato Nishimura, Pradeep Chaluvally-Raghavan, Takahito Miyake, ChadV Pecot, Sun Jin Kim, HyunJin Choi, FaridehZ Bischoff, JulieAnn Mayer, Li Huang, AlpaM Nick, CarolynS Hall, Cristian Rodriguez-Aguayo, Behrouz Zand, HeatherJ Dalton, Thiruvengadam Arumugam, HoJeong Lee, HeeDong HanMinSoon Cho, Rajesha Rupaimoole, LingegowdaS Mangala, Vasudha Sehgal, Sang Cheul Oh, Jinsong Liu, Ju Seog Lee, RobertL Coleman, Prahlad Ram, Gabriel Lopez-Berestein, IsaiahJ Fidler, AnilK Sood

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.

Original languageEnglish
Pages (from-to)77-91
Number of pages15
JournalCancer Cell
Volume26
Issue number1
DOIs
Publication statusPublished - 2014 Jul 14

Fingerprint

Ovarian Neoplasms
Omentum
Neoplasm Metastasis
Neuregulin-1
Parabiosis
Growth
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Pradeep, S., Kim, S., Wu, S., Nishimura, M., Chaluvally-Raghavan, P., Miyake, T., ... Sood, A. (2014). Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread. Cancer Cell, 26(1), 77-91. https://doi.org/10.1016/j.ccr.2014.05.002

Hematogenous Metastasis of Ovarian Cancer : Rethinking Mode of Spread. / Pradeep, Sunila; Kim, SeungW; Wu, SherryY; Nishimura, Masato; Chaluvally-Raghavan, Pradeep; Miyake, Takahito; Pecot, ChadV; Kim, Sun Jin; Choi, HyunJin; Bischoff, FaridehZ; Mayer, JulieAnn; Huang, Li; Nick, AlpaM; Hall, CarolynS; Rodriguez-Aguayo, Cristian; Zand, Behrouz; Dalton, HeatherJ; Arumugam, Thiruvengadam; Lee, HoJeong; Han, HeeDong; Cho, MinSoon; Rupaimoole, Rajesha; Mangala, LingegowdaS; Sehgal, Vasudha; Oh, Sang Cheul; Liu, Jinsong; Lee, Ju Seog; Coleman, RobertL; Ram, Prahlad; Lopez-Berestein, Gabriel; Fidler, IsaiahJ; Sood, AnilK.

In: Cancer Cell, Vol. 26, No. 1, 14.07.2014, p. 77-91.

Research output: Contribution to journalArticle

Pradeep, S, Kim, S, Wu, S, Nishimura, M, Chaluvally-Raghavan, P, Miyake, T, Pecot, C, Kim, SJ, Choi, H, Bischoff, F, Mayer, J, Huang, L, Nick, A, Hall, C, Rodriguez-Aguayo, C, Zand, B, Dalton, H, Arumugam, T, Lee, H, Han, H, Cho, M, Rupaimoole, R, Mangala, L, Sehgal, V, Oh, SC, Liu, J, Lee, JS, Coleman, R, Ram, P, Lopez-Berestein, G, Fidler, I & Sood, A 2014, 'Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread', Cancer Cell, vol. 26, no. 1, pp. 77-91. https://doi.org/10.1016/j.ccr.2014.05.002
Pradeep S, Kim S, Wu S, Nishimura M, Chaluvally-Raghavan P, Miyake T et al. Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread. Cancer Cell. 2014 Jul 14;26(1):77-91. https://doi.org/10.1016/j.ccr.2014.05.002
Pradeep, Sunila ; Kim, SeungW ; Wu, SherryY ; Nishimura, Masato ; Chaluvally-Raghavan, Pradeep ; Miyake, Takahito ; Pecot, ChadV ; Kim, Sun Jin ; Choi, HyunJin ; Bischoff, FaridehZ ; Mayer, JulieAnn ; Huang, Li ; Nick, AlpaM ; Hall, CarolynS ; Rodriguez-Aguayo, Cristian ; Zand, Behrouz ; Dalton, HeatherJ ; Arumugam, Thiruvengadam ; Lee, HoJeong ; Han, HeeDong ; Cho, MinSoon ; Rupaimoole, Rajesha ; Mangala, LingegowdaS ; Sehgal, Vasudha ; Oh, Sang Cheul ; Liu, Jinsong ; Lee, Ju Seog ; Coleman, RobertL ; Ram, Prahlad ; Lopez-Berestein, Gabriel ; Fidler, IsaiahJ ; Sood, AnilK. / Hematogenous Metastasis of Ovarian Cancer : Rethinking Mode of Spread. In: Cancer Cell. 2014 ; Vol. 26, No. 1. pp. 77-91.
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