Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

Sunila Pradeep, SeungW Kim, SherryY Wu, Masato Nishimura, Pradeep Chaluvally-Raghavan, Takahito Miyake, ChadV Pecot, Sun Jin Kim, HyunJin Choi, FaridehZ Bischoff, JulieAnn Mayer, Li Huang, AlpaM Nick, CarolynS Hall, Cristian Rodriguez-Aguayo, Behrouz Zand, HeatherJ Dalton, Thiruvengadam Arumugam, HoJeong Lee, HeeDong HanMinSoon Cho, Rajesha Rupaimoole, LingegowdaS Mangala, Vasudha Sehgal, Sang Cheul Oh, Jinsong Liu, Ju Seog Lee, RobertL Coleman, Prahlad Ram, Gabriel Lopez-Berestein, IsaiahJ Fidler, AnilK Sood

Research output: Contribution to journalArticle

139 Citations (Scopus)


Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.

Original languageEnglish
Pages (from-to)77-91
Number of pages15
JournalCancer Cell
Issue number1
Publication statusPublished - 2014 Jul 14

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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    Pradeep, S., Kim, S., Wu, S., Nishimura, M., Chaluvally-Raghavan, P., Miyake, T., Pecot, C., Kim, S. J., Choi, H., Bischoff, F., Mayer, J., Huang, L., Nick, A., Hall, C., Rodriguez-Aguayo, C., Zand, B., Dalton, H., Arumugam, T., Lee, H., ... Sood, A. (2014). Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread. Cancer Cell, 26(1), 77-91. https://doi.org/10.1016/j.ccr.2014.05.002