Hematopoietic effect of bacillus subtilis-fermented antler extract on phenylhydrazine-induced hemolytic anemia in sprague-dawley rats

Sang Hun Lee, Hyung Joo Suh, Hyun Sun Lee, Yooheon Park, Jang Woo Park, Eun Young Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study examined the effect of fermentation on the ability of antler to act as a stimulator of hematopoietic activity. Hemolytic anemia was induced by phenylhydrazine (PHZ) in female Sprague-Dawley rats. The vehicle or antler extract (nonfermented or fermented) mixed in drinking water was administered from Days 2 to 15 after PHZ injection. On Day 15, red blood cell counts in the fermented antler group (6.33×106/μL) were significantly higher than those in the nonfermented antler group (5.90×10 6/μL) (P<.05), and rats treated with fermented antler extract tended to have higher hemoglobin compared with rats treated with nonfermented antler extract, but not significantly. In addition, rats treated with fermented antler extract had slightly lower serum erythropoietin levels compared with nonfermented antler extract, which were not statistically different from serum erythropoietin levels of nonanemic rats. We conclude therefore that the hematopoietic activity of antler might be increased by the fermentation process.

Original languageEnglish
Pages (from-to)774-780
Number of pages7
JournalJournal of Medicinal Food
Volume15
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Antlers
Hemolytic Anemia
Bacillus subtilis
Sprague Dawley Rats
Erythropoietin
Fermentation
phenylhydrazine
Erythrocyte Count
Serum
Drinking Water
Hemoglobins

Keywords

  • erythropoietin
  • fermentation
  • hemoglobin
  • red blood cell

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Hematopoietic effect of bacillus subtilis-fermented antler extract on phenylhydrazine-induced hemolytic anemia in sprague-dawley rats. / Lee, Sang Hun; Suh, Hyung Joo; Lee, Hyun Sun; Park, Yooheon; Park, Jang Woo; Jung, Eun Young.

In: Journal of Medicinal Food, Vol. 15, No. 9, 01.09.2012, p. 774-780.

Research output: Contribution to journalArticle

Lee, Sang Hun ; Suh, Hyung Joo ; Lee, Hyun Sun ; Park, Yooheon ; Park, Jang Woo ; Jung, Eun Young. / Hematopoietic effect of bacillus subtilis-fermented antler extract on phenylhydrazine-induced hemolytic anemia in sprague-dawley rats. In: Journal of Medicinal Food. 2012 ; Vol. 15, No. 9. pp. 774-780.
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