Hematopoietic effect of fermented deer antler extract in iron deficient diet-induced anemic rats

Eun Young Jung, Yooheon Park, Moon Jea Woo, Sang Hun Lee, Hyung Joo Suh

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Abstract

Objective: To assess the hematopoietic effects of fermented deer antler extract using a dietinduced anemic animal model to facilitate the utilization of fermented deer antler extract and its derived products. Methods: Thirty 3-week-old female Sprague-Dawley rats were treated for 5 weeks. The rats were randomly divided into 6 groups and treated as follows: control, saline; NFA200, non-fermented deer antler extract 200 mg/kg; NFA500, non-fermented deer antler extract 500 mg/kg; FAB200, fermented deer antler extract 200 mg/kg; FAB500, fermented deer antler extract 500 mg/kg; and PC, heme iron 0.2 mg/kg. Blood parameters, iron content in the liver and spleen, hepatic δ-aminolevulinic acid dehydrogenase (ALAD) activity and divalent metal transporter 1 (DMT1) mRNA expression were analyzed. Results: No detectable significant differences were observed in blood parameters among groups. The decrease in the hepatic ALAD activity in anemic rats was significantly improved by fermented deer antler extract supplementation (P0.05). The hepatic DMT1 mRNA expression level was increased significantly by supplementation with both the fermented deer antler extract and the non-fermented deer antler extract in a dose-dependent manner compared with nontreatment in anemic rats (P

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalChinese Journal of Integrative Medicine
DOIs
Publication statusAccepted/In press - 2016 Jul 28

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Keywords

  • deer antler
  • divalent metal transporter 1
  • fermentation
  • iron deficiency anemia
  • δ-aminolevulinic acid dehydrogenase

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Pharmacology (medical)

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