Hematuria and proteinuria in a mass school urine screening test

Yong Hoon Park, Jung Youn Choi, Hyo Seok Chung, Ja Wook Koo, Su Yung Kim, Mee Kyung Namgoong, Young Seo Park, Kee Hwan Yoo, Kyung Yil Lee, Dae Yeol Lee, Seung Joo Lee, Ji Eun Lee, Woo Yeong Chung, Tae Sun Hah, Hae Il Cheong, Yong Choi, Kyung Soo Lee

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62 Citations (Scopus)

Abstract

A total of 1,044 school children identified with hematuria and/or proteinuria during a mass school urine screening test were referred to pediatric nephrologists at 13 hospitals in Korea. These children had isolated hematuria (IH) (60.1%), isolated proteinuria (IP) (26.4%: transient, 19.6%; orthostatic, 4.9%; persistent, 1.9%) or combined hematuria and proteinuria (CHP) (13.5%). The patient's history, physical examination, laboratory tests, kidney ultrasound and Doppler ultrasonography were obtained. Renal biopsies were performed on 113 children who showed severe proteinuria, hypertension, abnormal renal function, family history of chronic renal disease, systemic diseases or persistent hematuria and/or proteinuria for more than 12 months. IgA nephropathy (IgAN), thin basement membrane nephropathy (TBMN), membranoproliferative glomerulonephritis (MPGN), focal segmental glomerulosclerosis (FSGS), other GN, Alport syndrome and lupus nephritis were detected. IgAN and TBMN were the most common causes in the CHP group and IH group, respectively. Abnormal findings on the renal ultrasound with or without Doppler ultrasonography were noted in 147 cases (suspected nutcracker phenomenon, 65; increased parenchymal echogenicity, 40; hydronephrosis, 15). This study showed that the use of a mass school urine screening program can detect chronic renal disease in its early stage and recommends that more attention should be paid to identifying those children with CHP and massive proteinuria. A school urine screening program can detect chronic renal disease in its early stage. When mass screening is used, the initial aggressive diagnostic procedures such as renal biopsy are not needed. In addition, a regular follow-up for those children with IH and IP is certainly warranted.

Original languageEnglish
Pages (from-to)1126-1130
Number of pages5
JournalPediatric Nephrology
Volume20
Issue number8
DOIs
Publication statusPublished - 2005 Aug

Keywords

  • Chronic renal disease
  • Hematuria
  • Proteinuria
  • Schoolurine mass screening

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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