Hemodynamic analysis of coronary artery microcirculation using a pig's morphometric data

Sehyun Shin, Jungsu Park

Research output: Contribution to journalArticle

Abstract

Stenosed coronary artery may play an important role in various coronary heart diseases. However, it has not been known how much stenosed coronary artery affects coronary circulation system, quantitatively. The present study developed a mathematical model for microcirculation in the left common coronary artery (LCCA) with adopting a previously measured morphological data and mechanical properties of the coronary vessels. We examine the effect of percent diameter stenosis on blood flow rate and shear stress for two cases. Case I comprised of onestenosed element at 10th order (% diameter stenosis are 10, 30, and 50, respectively). Case II consisted of completely occluded element at 10th order (number of occluded elements are 0, 1, and 2 out of 8, respectively). As the level of stenosis becomes severe, the shear stress increases significantly but the flow rate reduction was relatively small. However, for the occluded case, there was linearly proportional reduction of flow rate according to number of occluded elements. Either such high shear stress associated with coronary artery stenosis or reduced flow rate due to occlusion may cause atherosclerosis and myocardial ischemia.

Original languageEnglish
Pages (from-to)1313-1320
Number of pages8
JournalJournal of Mechanical Science and Technology
Volume19
Issue number6
Publication statusPublished - 2005 Jun 1
Externally publishedYes

Fingerprint

Microcirculation
Hemodynamics
Flow rate
Shear stress
Blood
Mathematical models
Mechanical properties

Keywords

  • Hemodynamics
  • Left common Coronary Artery (LCCA)
  • Occlusion
  • Stenosis

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Hemodynamic analysis of coronary artery microcirculation using a pig's morphometric data. / Shin, Sehyun; Park, Jungsu.

In: Journal of Mechanical Science and Technology, Vol. 19, No. 6, 01.06.2005, p. 1313-1320.

Research output: Contribution to journalArticle

@article{2be8acdd69b24300bf1ecad9476f382b,
title = "Hemodynamic analysis of coronary artery microcirculation using a pig's morphometric data",
abstract = "Stenosed coronary artery may play an important role in various coronary heart diseases. However, it has not been known how much stenosed coronary artery affects coronary circulation system, quantitatively. The present study developed a mathematical model for microcirculation in the left common coronary artery (LCCA) with adopting a previously measured morphological data and mechanical properties of the coronary vessels. We examine the effect of percent diameter stenosis on blood flow rate and shear stress for two cases. Case I comprised of onestenosed element at 10th order ({\%} diameter stenosis are 10, 30, and 50, respectively). Case II consisted of completely occluded element at 10th order (number of occluded elements are 0, 1, and 2 out of 8, respectively). As the level of stenosis becomes severe, the shear stress increases significantly but the flow rate reduction was relatively small. However, for the occluded case, there was linearly proportional reduction of flow rate according to number of occluded elements. Either such high shear stress associated with coronary artery stenosis or reduced flow rate due to occlusion may cause atherosclerosis and myocardial ischemia.",
keywords = "Hemodynamics, Left common Coronary Artery (LCCA), Occlusion, Stenosis",
author = "Sehyun Shin and Jungsu Park",
year = "2005",
month = "6",
day = "1",
language = "English",
volume = "19",
pages = "1313--1320",
journal = "Journal of Mechanical Science and Technology",
issn = "1738-494X",
publisher = "Korean Society of Mechanical Engineers",
number = "6",

}

TY - JOUR

T1 - Hemodynamic analysis of coronary artery microcirculation using a pig's morphometric data

AU - Shin, Sehyun

AU - Park, Jungsu

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Stenosed coronary artery may play an important role in various coronary heart diseases. However, it has not been known how much stenosed coronary artery affects coronary circulation system, quantitatively. The present study developed a mathematical model for microcirculation in the left common coronary artery (LCCA) with adopting a previously measured morphological data and mechanical properties of the coronary vessels. We examine the effect of percent diameter stenosis on blood flow rate and shear stress for two cases. Case I comprised of onestenosed element at 10th order (% diameter stenosis are 10, 30, and 50, respectively). Case II consisted of completely occluded element at 10th order (number of occluded elements are 0, 1, and 2 out of 8, respectively). As the level of stenosis becomes severe, the shear stress increases significantly but the flow rate reduction was relatively small. However, for the occluded case, there was linearly proportional reduction of flow rate according to number of occluded elements. Either such high shear stress associated with coronary artery stenosis or reduced flow rate due to occlusion may cause atherosclerosis and myocardial ischemia.

AB - Stenosed coronary artery may play an important role in various coronary heart diseases. However, it has not been known how much stenosed coronary artery affects coronary circulation system, quantitatively. The present study developed a mathematical model for microcirculation in the left common coronary artery (LCCA) with adopting a previously measured morphological data and mechanical properties of the coronary vessels. We examine the effect of percent diameter stenosis on blood flow rate and shear stress for two cases. Case I comprised of onestenosed element at 10th order (% diameter stenosis are 10, 30, and 50, respectively). Case II consisted of completely occluded element at 10th order (number of occluded elements are 0, 1, and 2 out of 8, respectively). As the level of stenosis becomes severe, the shear stress increases significantly but the flow rate reduction was relatively small. However, for the occluded case, there was linearly proportional reduction of flow rate according to number of occluded elements. Either such high shear stress associated with coronary artery stenosis or reduced flow rate due to occlusion may cause atherosclerosis and myocardial ischemia.

KW - Hemodynamics

KW - Left common Coronary Artery (LCCA)

KW - Occlusion

KW - Stenosis

UR - http://www.scopus.com/inward/record.url?scp=20744441115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20744441115&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:20744441115

VL - 19

SP - 1313

EP - 1320

JO - Journal of Mechanical Science and Technology

JF - Journal of Mechanical Science and Technology

SN - 1738-494X

IS - 6

ER -