Hemodynamic Features of Microsurgically Identified, Thin-Walled Regions of Unruptured Middle Cerebral Artery Aneurysms Characterized Using Computational Fluid Dynamics

Jang Hun Kim, Huan Han, Young June Moon, Sangil Suh, Taek Hyun Kwon, Jong Hyun Kim, Kyuha Chong, Won Ki Yoon

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Thin-walled regions (TWRs) of aneurysm surfaces observed in microscopic surgery are thought to be vulnerable areas for growth and rupture of unruptured intracranial aneurysms (UIAs). OBJECTIVE: To identify hemodynamic features of TWRs of aneurysms by using computational fluid dynamics (CFD) analyses of unruptured middle cerebral artery bifurcation (MCAB) aneurysms. METHODS: Nine patients with 11 MCAB aneurysms were enrolled, and their TWRs were identified. CFD analysis was performed using 3 parameters: pressure, wall shear stress (WSS), and WSS divergence (WSSD). Each parameter was evaluated for its correspondence with TWR. RESULTS: Among 11 aneurysms, 15 TWRs were identified. Corresponding matches with CFD parameters (pressure, WSS, and WSSD) were 73.33, 46.67, and 86.67%, respectively. CONCLUSION: WSSD, a hemodynamic parameter that accounts for both magnitude and directionality of WSS, showed the highest correspondence. High WSSD might correspond with TWR of intracranial aneurysms, which are likely high-risk areas for rupture.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalNeurosurgery
Volume86
Issue number6
DOIs
Publication statusPublished - 2020 Jun 1

Keywords

  • Aneurysm
  • Computational fluid dynamics
  • Thin-walled region
  • Wall shear stress divergence

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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