Hemodynamic responses in rat brain during transcranial direct current stimulation: A functional near-infrared spectroscopy study

Chang Hee Han, Hyuna Song, Yong Guk Kang, Beop-Min Kim, Chang Hwan Im

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven rats received transcranial anodal stimulation with 200 μA direct current (DC) on their right barrel cortex for 10 min. The concentration changes of oxygenated hemoglobin (oxy-Hb) were continuously monitored during stimulation (10 min) and after stimulation (20 min). The trend of hemodynamic response changes was modeled using linear regression, and the relationship between incremental and decremental rates of oxy-Hb was investigated by correlation analysis. Our results showed that the oxy-Hb concentration was almost linearly increased and decreased during and after stimulation, respectively. In addition, a significant negative correlation (p <0.05) was found between the rate of increase of oxy-Hb during stimulation and the rate of decrease of oxy-Hb after stimulation, indicating that the recovery time after tDCS may not depend on the total amount of hemodynamic changes in the stimulated brain area. Our results also demonstrated considerable individual variability in the rate of change of hemodynamic responses even with the same direct current dose to identical brain regions. This suggests that individual differences in tDCS after-effects may originate from intrinsic differences in the speed of DC stimulation “uptake” rather than differences in the total capacity of DC uptake, and thus the stimulation parameters may need to be customized for each individual in order to maximize tDCS after-effects.

Original languageEnglish
Article numberA1812
Pages (from-to)1812-1821
Number of pages10
JournalBiomedical Optics Express
Volume5
Issue number6
DOIs
Publication statusPublished - 2014 Jun 1

Fingerprint

hemodynamic responses
Near-Infrared Spectroscopy
stimulation
rats
brain
Hemoglobins
Hemodynamics
direct current
infrared spectroscopy
Brain
hemoglobin
Individuality
Linear Models
Transcranial Direct Current Stimulation
hemodynamics
cortexes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Hemodynamic responses in rat brain during transcranial direct current stimulation : A functional near-infrared spectroscopy study. / Han, Chang Hee; Song, Hyuna; Kang, Yong Guk; Kim, Beop-Min; Im, Chang Hwan.

In: Biomedical Optics Express, Vol. 5, No. 6, A1812, 01.06.2014, p. 1812-1821.

Research output: Contribution to journalArticle

@article{3be02e2ab7e74fbbabac542fc21e1a31,
title = "Hemodynamic responses in rat brain during transcranial direct current stimulation: A functional near-infrared spectroscopy study",
abstract = "In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven rats received transcranial anodal stimulation with 200 μA direct current (DC) on their right barrel cortex for 10 min. The concentration changes of oxygenated hemoglobin (oxy-Hb) were continuously monitored during stimulation (10 min) and after stimulation (20 min). The trend of hemodynamic response changes was modeled using linear regression, and the relationship between incremental and decremental rates of oxy-Hb was investigated by correlation analysis. Our results showed that the oxy-Hb concentration was almost linearly increased and decreased during and after stimulation, respectively. In addition, a significant negative correlation (p <0.05) was found between the rate of increase of oxy-Hb during stimulation and the rate of decrease of oxy-Hb after stimulation, indicating that the recovery time after tDCS may not depend on the total amount of hemodynamic changes in the stimulated brain area. Our results also demonstrated considerable individual variability in the rate of change of hemodynamic responses even with the same direct current dose to identical brain regions. This suggests that individual differences in tDCS after-effects may originate from intrinsic differences in the speed of DC stimulation “uptake” rather than differences in the total capacity of DC uptake, and thus the stimulation parameters may need to be customized for each individual in order to maximize tDCS after-effects.",
author = "Han, {Chang Hee} and Hyuna Song and Kang, {Yong Guk} and Beop-Min Kim and Im, {Chang Hwan}",
year = "2014",
month = "6",
day = "1",
doi = "10.1364/BOE.5.001812",
language = "English",
volume = "5",
pages = "1812--1821",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "6",

}

TY - JOUR

T1 - Hemodynamic responses in rat brain during transcranial direct current stimulation

T2 - A functional near-infrared spectroscopy study

AU - Han, Chang Hee

AU - Song, Hyuna

AU - Kang, Yong Guk

AU - Kim, Beop-Min

AU - Im, Chang Hwan

PY - 2014/6/1

Y1 - 2014/6/1

N2 - In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven rats received transcranial anodal stimulation with 200 μA direct current (DC) on their right barrel cortex for 10 min. The concentration changes of oxygenated hemoglobin (oxy-Hb) were continuously monitored during stimulation (10 min) and after stimulation (20 min). The trend of hemodynamic response changes was modeled using linear regression, and the relationship between incremental and decremental rates of oxy-Hb was investigated by correlation analysis. Our results showed that the oxy-Hb concentration was almost linearly increased and decreased during and after stimulation, respectively. In addition, a significant negative correlation (p <0.05) was found between the rate of increase of oxy-Hb during stimulation and the rate of decrease of oxy-Hb after stimulation, indicating that the recovery time after tDCS may not depend on the total amount of hemodynamic changes in the stimulated brain area. Our results also demonstrated considerable individual variability in the rate of change of hemodynamic responses even with the same direct current dose to identical brain regions. This suggests that individual differences in tDCS after-effects may originate from intrinsic differences in the speed of DC stimulation “uptake” rather than differences in the total capacity of DC uptake, and thus the stimulation parameters may need to be customized for each individual in order to maximize tDCS after-effects.

AB - In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven rats received transcranial anodal stimulation with 200 μA direct current (DC) on their right barrel cortex for 10 min. The concentration changes of oxygenated hemoglobin (oxy-Hb) were continuously monitored during stimulation (10 min) and after stimulation (20 min). The trend of hemodynamic response changes was modeled using linear regression, and the relationship between incremental and decremental rates of oxy-Hb was investigated by correlation analysis. Our results showed that the oxy-Hb concentration was almost linearly increased and decreased during and after stimulation, respectively. In addition, a significant negative correlation (p <0.05) was found between the rate of increase of oxy-Hb during stimulation and the rate of decrease of oxy-Hb after stimulation, indicating that the recovery time after tDCS may not depend on the total amount of hemodynamic changes in the stimulated brain area. Our results also demonstrated considerable individual variability in the rate of change of hemodynamic responses even with the same direct current dose to identical brain regions. This suggests that individual differences in tDCS after-effects may originate from intrinsic differences in the speed of DC stimulation “uptake” rather than differences in the total capacity of DC uptake, and thus the stimulation parameters may need to be customized for each individual in order to maximize tDCS after-effects.

UR - http://www.scopus.com/inward/record.url?scp=84928161967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928161967&partnerID=8YFLogxK

U2 - 10.1364/BOE.5.001812

DO - 10.1364/BOE.5.001812

M3 - Article

AN - SCOPUS:84928161967

VL - 5

SP - 1812

EP - 1821

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 6

M1 - A1812

ER -