Hemodynamic responses in rat brain during transcranial direct current stimulation: A functional near-infrared spectroscopy study

Chang Hee Han, Hyuna Song, Yong Guk Kang, Beop Min Kim, Chang Hwan Im

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22 Citations (Scopus)


In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven rats received transcranial anodal stimulation with 200 μA direct current (DC) on their right barrel cortex for 10 min. The concentration changes of oxygenated hemoglobin (oxy-Hb) were continuously monitored during stimulation (10 min) and after stimulation (20 min). The trend of hemodynamic response changes was modeled using linear regression, and the relationship between incremental and decremental rates of oxy-Hb was investigated by correlation analysis. Our results showed that the oxy-Hb concentration was almost linearly increased and decreased during and after stimulation, respectively. In addition, a significant negative correlation (p < 0.05) was found between the rate of increase of oxy-Hb during stimulation and the rate of decrease of oxy-Hb after stimulation, indicating that the recovery time after tDCS may not depend on the total amount of hemodynamic changes in the stimulated brain area. Our results also demonstrated considerable individual variability in the rate of change of hemodynamic responses even with the same direct current dose to identical brain regions. This suggests that individual differences in tDCS after-effects may originate from intrinsic differences in the speed of DC stimulation “uptake” rather than differences in the total capacity of DC uptake, and thus the stimulation parameters may need to be customized for each individual in order to maximize tDCS after-effects.

Original languageEnglish
Article numberA1812
Pages (from-to)1812-1821
Number of pages10
JournalBiomedical Optics Express
Issue number6
Publication statusPublished - 2014 Jun 1

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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