Hemodynamic responses of rat brain measured by near-infrared spectroscopy during various whisker stimulations

Seungduk Lee, Dalkwon Koh, Kiwoon Kwon, Hyun Joo Lee, Yiran Lang, Hyung Cheul Shin, Beop-Min Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

NIRS (Near-infrared spectroscopy) is a relatively, new, non-invasive, and non-ionizing method of measuring hemodynamic responses in thick biological tissues such as the cerebral cortex. In this study, we measured the hemodynamic responses of the rat barrel cortex to whisker stimulation by using a frequency-domain NIRS system. We designed multiple optical probes comprising multimode optical fibers and manipulating arms, both of which can be easily applied to small animals. Various electrical stimulations were applied to rat whiskers at different voltage levels and stimulation frequencies. Our results show that the hemodynamic responses are highly dependent on the stimulation voltage level, and not so much on stimulation frequency. This paper suggests that NIRS technology is highly suitable for the study of small animal brains.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalJournal of the Optical Society of Korea
Volume13
Issue number1
DOIs
Publication statusPublished - 2009 Dec 4

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hemodynamic responses
stimulation
rats
brain
infrared spectroscopy
animals
cerebral cortex
cortexes
electric potential
optical fibers
probes

Keywords

  • Hemodynamic responses
  • Near-infrared spectroscopy (NIRS)
  • Neuroimaging
  • Neurovascular coupling
  • Whisker stimulation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Hemodynamic responses of rat brain measured by near-infrared spectroscopy during various whisker stimulations. / Lee, Seungduk; Koh, Dalkwon; Kwon, Kiwoon; Lee, Hyun Joo; Lang, Yiran; Shin, Hyung Cheul; Kim, Beop-Min.

In: Journal of the Optical Society of Korea, Vol. 13, No. 1, 04.12.2009, p. 166-170.

Research output: Contribution to journalArticle

Lee, Seungduk ; Koh, Dalkwon ; Kwon, Kiwoon ; Lee, Hyun Joo ; Lang, Yiran ; Shin, Hyung Cheul ; Kim, Beop-Min. / Hemodynamic responses of rat brain measured by near-infrared spectroscopy during various whisker stimulations. In: Journal of the Optical Society of Korea. 2009 ; Vol. 13, No. 1. pp. 166-170.
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