Hemodynamic responses of rat brain measured by near-infrared spectroscopy during various whisker stimulations

Seungduk Lee, Dalkwon Koh, Kiwoon Kwon, Hyun Joo Lee, Yiran Lang, Hyung Cheul Shin, Beop Min Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)


NIRS (Near-infrared spectroscopy) is a relatively, new, non-invasive, and non-ionizing method of measuring hemodynamic responses in thick biological tissues such as the cerebral cortex. In this study, we measured the hemodynamic responses of the rat barrel cortex to whisker stimulation by using a frequency-domain NIRS system. We designed multiple optical probes comprising multimode optical fibers and manipulating arms, both of which can be easily applied to small animals. Various electrical stimulations were applied to rat whiskers at different voltage levels and stimulation frequencies. Our results show that the hemodynamic responses are highly dependent on the stimulation voltage level, and not so much on stimulation frequency. This paper suggests that NIRS technology is highly suitable for the study of small animal brains.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalJournal of the Optical Society of Korea
Issue number1
Publication statusPublished - 2009 Dec 4



  • Hemodynamic responses
  • Near-infrared spectroscopy (NIRS)
  • Neuroimaging
  • Neurovascular coupling
  • Whisker stimulation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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