Hemorheological changes caused by lead exposure

C. B. Kim; Sehyun Shin; Seok Heung Song

doi:10.3233/CH-2012-1641

Hemorheological changes caused by lead exposure

C. B. Kim, Sehyun Shin, Seok Heung Song

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.

Original language	English
Pages (from-to)	341-348
Number of pages	8
Journal	Clinical Hemorheology and Microcirculation
Volume	55
Issue number	3
DOIs	https://doi.org/10.3233/CH-2012-1641
Publication status	Published - 2013

Keywords

Aggregation
Deformability
Hemorheology
Lead
Toxicology

ASJC Scopus subject areas

Physiology
Hematology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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AB - Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.

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KW - Lead

KW - Toxicology

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Hemorheological changes caused by lead exposure

Abstract

Keywords

ASJC Scopus subject areas

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