Abstract
Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.
| Original language | English |
|---|---|
| Pages (from-to) | 341-348 |
| Number of pages | 8 |
| Journal | Clinical Hemorheology and Microcirculation |
| Volume | 55 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Dec 31 |
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Keywords
- Aggregation
- Deformability
- Hemorheology
- Lead
- Toxicology
ASJC Scopus subject areas
- Hematology
- Physiology
- Physiology (medical)
- Cardiology and Cardiovascular Medicine
Cite this
Hemorheological changes caused by lead exposure. / Kim, C. B.; Shin, Sehyun; Song, Seok Heung.
In: Clinical Hemorheology and Microcirculation, Vol. 55, No. 3, 31.12.2013, p. 341-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemorheological changes caused by lead exposure
AU - Kim, C. B.
AU - Shin, Sehyun
AU - Song, Seok Heung
PY - 2013/12/31
Y1 - 2013/12/31
N2 - Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.
AB - Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.
KW - Aggregation
KW - Deformability
KW - Hemorheology
KW - Lead
KW - Toxicology
UR - http://www.scopus.com/inward/record.url?scp=84891079141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891079141&partnerID=8YFLogxK
U2 - 10.3233/CH-2012-1641
DO - 10.3233/CH-2012-1641
M3 - Article
VL - 55
SP - 341
EP - 348
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
SN - 1386-0291
IS - 3
ER -