Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice

Jin Hee Seo, Eui Suk Jeong, Kyoung Sun Lee, Seung Ho Heo, Dong Gu Jeong, Sung-Joon Lee, Eun Soo Kim, Yang Kyu Choi

Research output: Contribution to journalArticle

Abstract

he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.

Original languageEnglish
Pages (from-to)927-932
Number of pages6
JournalFood Science and Biotechnology
Volume21
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

Fingerprint

apolipoprotein E
Apolipoproteins E
atherosclerosis
Knockout Mice
Atherosclerosis
Water
mice
extracts
water
Sinus of Valsalva
sinuses
low density lipoprotein cholesterol
water activity
risk factors
LDL Cholesterol
Weight Gain
weight gain
cholesterol
Cholesterol
Pharmacology

Keywords

  • apolipoprotein E knockout mice
  • atherosclerosis
  • hempseed
  • low-density lipoprotein

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice. / Seo, Jin Hee; Jeong, Eui Suk; Lee, Kyoung Sun; Heo, Seung Ho; Jeong, Dong Gu; Lee, Sung-Joon; Kim, Eun Soo; Choi, Yang Kyu.

In: Food Science and Biotechnology, Vol. 21, No. 4, 01.08.2012, p. 927-932.

Research output: Contribution to journalArticle

Seo, Jin Hee ; Jeong, Eui Suk ; Lee, Kyoung Sun ; Heo, Seung Ho ; Jeong, Dong Gu ; Lee, Sung-Joon ; Kim, Eun Soo ; Choi, Yang Kyu. / Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice. In: Food Science and Biotechnology. 2012 ; Vol. 21, No. 4. pp. 927-932.
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