Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice

Jin Hee Seo; Eui Suk Jeong; Kyoung Sun Lee; Seung Ho Heo; Dong Gu Jeong; Sung Joon Lee; Eun Soo Kim; Yang Kyu Choi

doi:10.1007/s10068-012-0122-1

Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice

Jin Hee Seo, Eui Suk Jeong, Kyoung Sun Lee, Seung Ho Heo, Dong Gu Jeong, Sung Joon Lee, Eun Soo Kim, Yang Kyu Choi

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.

Original language	English
Pages (from-to)	927-932
Number of pages	6
Journal	Food Science and Biotechnology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1007/s10068-012-0122-1
Publication status	Published - 2012 Aug

Keywords

apolipoprotein E knockout mice
atherosclerosis
hempseed
low-density lipoprotein

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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title = "Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice",

abstract = "he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.",

keywords = "apolipoprotein E knockout mice, atherosclerosis, hempseed, low-density lipoprotein",

author = "Seo, {Jin Hee} and Jeong, {Eui Suk} and Lee, {Kyoung Sun} and Heo, {Seung Ho} and Jeong, {Dong Gu} and Lee, {Sung Joon} and Kim, {Eun Soo} and Choi, {Yang Kyu}",

year = "2012",

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T1 - Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice

AU - Seo, Jin Hee

AU - Jeong, Eui Suk

AU - Lee, Kyoung Sun

AU - Heo, Seung Ho

AU - Jeong, Dong Gu

AU - Lee, Sung Joon

AU - Kim, Eun Soo

AU - Choi, Yang Kyu

PY - 2012/8

Y1 - 2012/8

N2 - he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.

AB - he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.

KW - apolipoprotein E knockout mice

KW - atherosclerosis

KW - hempseed

KW - low-density lipoprotein

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