Abstract
he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.
| Original language | English |
|---|---|
| Pages (from-to) | 927-932 |
| Number of pages | 6 |
| Journal | Food Science and Biotechnology |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 Aug 1 |
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Keywords
- apolipoprotein E knockout mice
- atherosclerosis
- hempseed
- low-density lipoprotein
ASJC Scopus subject areas
- Food Science
- Biotechnology
- Applied Microbiology and Biotechnology
Cite this
Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice. / Seo, Jin Hee; Jeong, Eui Suk; Lee, Kyoung Sun; Heo, Seung Ho; Jeong, Dong Gu; Lee, Sung-Joon; Kim, Eun Soo; Choi, Yang Kyu.
In: Food Science and Biotechnology, Vol. 21, No. 4, 01.08.2012, p. 927-932.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice
AU - Seo, Jin Hee
AU - Jeong, Eui Suk
AU - Lee, Kyoung Sun
AU - Heo, Seung Ho
AU - Jeong, Dong Gu
AU - Lee, Sung-Joon
AU - Kim, Eun Soo
AU - Choi, Yang Kyu
PY - 2012/8/1
Y1 - 2012/8/1
N2 - he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.
AB - he principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.
KW - apolipoprotein E knockout mice
KW - atherosclerosis
KW - hempseed
KW - low-density lipoprotein
UR - http://www.scopus.com/inward/record.url?scp=84866092327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866092327&partnerID=8YFLogxK
U2 - 10.1007/s10068-012-0122-1
DO - 10.1007/s10068-012-0122-1
M3 - Article
AN - SCOPUS:84866092327
VL - 21
SP - 927
EP - 932
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
SN - 1226-7708
IS - 4
ER -