Heparin-Coated gold nanopartieles for liver-Specific CT imaging

In Cheol Sun, Dae Kyung Eun, Jin Hee Na, Seulki Lee, I. I.Jin Kim, In Chan Youn, Chang Yong Ko, Han Sung Kim, Dohyung Lim, Kuiwon Choi, Phillip B. Messersmith, Tae Gwan Park, Sang Yoon Kim, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

Research output: Contribution to journal › Article

122 Citations (Scopus)

Abstract

"Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

Original languageEnglish
Pages (from-to)13341-13347+13276
JournalChemistry - A European Journal
Volume15
Issue number48
DOIs
Publication statusPublished - 2009 Dec 14

Keywords

  • Computed tomography
  • Gold
  • Heparin
  • Imaging agents
  • Nanoparticles

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Sun, I. C., Eun, D. K., Na, J. H., Lee, S., Kim, I. I. J., Youn, I. C., Ko, C. Y., Kim, H. S., Lim, D., Choi, K., Messersmith, P. B., Park, T. G., Kim, S. Y., Kwon, I. C., Kim, K., & Ahn, C. H. (2009). Heparin-Coated gold nanopartieles for liver-Specific CT imaging. Chemistry - A European Journal, 15(48), 13341-13347+13276. https://doi.org/10.1002/chem.200902344