Heparin-conjugated star-shaped PLA for improved biocompatibility

Hyun Go Dong, Ki Joung Yoon, Young Park Sun, Yongdoo Park, Ki Dong Park

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Star-shaped PLA-heparin (sPLA-Hep) was prepared by coupling heparin to the star-shaped PLA (sPLA) reaction using carbonyldiimidazole (CDI) chemistry. Hydroxyl groups of sPLA were activated by CDI for the reaction with the remained amino-tenninal groups of heparin. The surface heparin content of sPLA-Hep was measured to be 1.43 μg/cm2. sPLA-Hep-coated surface has shown higher hydrophilicity than control surface. The clotting time of sPLA-Hep measured by activated partial thromboplastin time (APTT) was significantly prolonged when compared with sPLA and linear PLA-Hep. sPLA-Hep surface demonstrated lower protein adsorption and platelet adhesion than control sPLA surface. In addition, fibroblast culture on the sPLA-Hep surface showed the enhanced cell spreading area compared with the sPLA surface. Obtained results suggest that the incorporation of heparin to sPLA is effective in curtailing the surface induced-thrombosis and in manipulating the cell interaction. sPLA-Hep could be applied as blood/tissue compatible biodegradable materials for implantable medical devices and tissue engineering.

Original languageEnglish
Pages (from-to)842-848
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume86
Issue number3
DOIs
Publication statusPublished - 2008 Sep 1

    Fingerprint

Keywords

  • Blood compatibility
  • Heparin
  • Polylactide
  • Tissue compatibility

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this