Heparin release from polymer complex

Ick Chan Kwon, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

An electro-erodible polyelectrolyte complex was prepared and investigated for a pulsatile drug release system. An insoluble polyelectrolyte complex was formed by combining two water-soluble polymers, poly(allylamine) and heparin. Upon the application of an electric current, a rapid structural change of the complex occurred, dissolving the polymer matrix in proportion to the intensity of an applied electric current. The disruption of ionic bonds in the polymer matrix attached to the cathode and subsequent release of heparin was due to the locally increased pH near the cathode (resulting from hydroxyl ion production). Thus, the release pattern of a model bioactive macromolecule, heparin, followed the applied electric current, primarily due to surface erosion of the polymer matrix.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Controlled Release
Volume30
Issue number2
Publication statusPublished - 1994 May 1
Externally publishedYes

Fingerprint

Heparin
Polymers
Electrodes
Allylamine
Water
Polyelectrolytes

Keywords

  • Drug delivery system
  • Heparin
  • Polyelectrolyte complex
  • Pulsatile release
  • Stimuli sensitive polymer

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Kwon, I. C., Bae, Y. H., & Kim, S. W. (1994). Heparin release from polymer complex. Journal of Controlled Release, 30(2), 155-159.

Heparin release from polymer complex. / Kwon, Ick Chan; Bae, You Han; Kim, Sung Wan.

In: Journal of Controlled Release, Vol. 30, No. 2, 01.05.1994, p. 155-159.

Research output: Contribution to journalArticle

Kwon, IC, Bae, YH & Kim, SW 1994, 'Heparin release from polymer complex', Journal of Controlled Release, vol. 30, no. 2, pp. 155-159.
Kwon IC, Bae YH, Kim SW. Heparin release from polymer complex. Journal of Controlled Release. 1994 May 1;30(2):155-159.
Kwon, Ick Chan ; Bae, You Han ; Kim, Sung Wan. / Heparin release from polymer complex. In: Journal of Controlled Release. 1994 ; Vol. 30, No. 2. pp. 155-159.
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