TY - JOUR
T1 - Heparin release from polymer complex
AU - Kwon, Ick Chan
AU - Bae, You Han
AU - Kim, Sung Wan
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1994/5
Y1 - 1994/5
N2 - An electro-erodible polyelectrolyte complex was prepared and investigated for a pulsatile drug release system. An insoluble polyelectrolyte complex was formed by combining two water-soluble polymers, poly(allylamine) and heparin. Upon the application of an electric current, a rapid structural change of the complex occurred, dissolving the polymer matrix in proportion to the intensity of an applied electric current. The disruption of ionic bonds in the polymer matrix attached to the cathode and subsequent release of heparin was due to the locally increased pH near the cathode (resulting from hydroxyl ion production). Thus, the release pattern of a model bioactive macromolecule, heparin, followed the applied electric current, primarily due to surface erosion of the polymer matrix.
AB - An electro-erodible polyelectrolyte complex was prepared and investigated for a pulsatile drug release system. An insoluble polyelectrolyte complex was formed by combining two water-soluble polymers, poly(allylamine) and heparin. Upon the application of an electric current, a rapid structural change of the complex occurred, dissolving the polymer matrix in proportion to the intensity of an applied electric current. The disruption of ionic bonds in the polymer matrix attached to the cathode and subsequent release of heparin was due to the locally increased pH near the cathode (resulting from hydroxyl ion production). Thus, the release pattern of a model bioactive macromolecule, heparin, followed the applied electric current, primarily due to surface erosion of the polymer matrix.
KW - Drug delivery system
KW - Heparin
KW - Polyelectrolyte complex
KW - Pulsatile release
KW - Stimuli sensitive polymer
UR - http://www.scopus.com/inward/record.url?scp=0028338358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028338358&partnerID=8YFLogxK
U2 - 10.1016/0168-3659(94)90262-3
DO - 10.1016/0168-3659(94)90262-3
M3 - Article
AN - SCOPUS:0028338358
VL - 30
SP - 155
EP - 159
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 2
ER -