Heparin release from polymer complex

Ick Chan Kwon, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

An electro-erodible polyelectrolyte complex was prepared and investigated for a pulsatile drug release system. An insoluble polyelectrolyte complex was formed by combining two water-soluble polymers, poly(allylamine) and heparin. Upon the application of an electric current, a rapid structural change of the complex occurred, dissolving the polymer matrix in proportion to the intensity of an applied electric current. The disruption of ionic bonds in the polymer matrix attached to the cathode and subsequent release of heparin was due to the locally increased pH near the cathode (resulting from hydroxyl ion production). Thus, the release pattern of a model bioactive macromolecule, heparin, followed the applied electric current, primarily due to surface erosion of the polymer matrix.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Controlled Release
Volume30
Issue number2
DOIs
Publication statusPublished - 1994 May

Keywords

  • Drug delivery system
  • Heparin
  • Polyelectrolyte complex
  • Pulsatile release
  • Stimuli sensitive polymer

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Heparin release from polymer complex'. Together they form a unique fingerprint.

Cite this