Hepatic and Small Bowel Mucormycosis after Chemotherapy in a Patient with Acute Myeloid Leukemia: A Case Report and Literature Review

Tae Un Yang, Sun Hwa Kim, Byeong Kwang Choi, Soon Wook Lee, Joo Hee Park, Kyung Wook Hong, In Sun Kim, Yu Bin Seo, Chul Won Choi, Woo Joo Kim

Research output: Contribution to journalArticle

Abstract

We present a case of a 64-year-old woman with acute myeloid leukemia who developed a hepatic abscess during the neutropenic period after induction chemotherapy. To treat the abscess, meropenem and ciprofloxacin were administered to target Klebsiella pneumoniae and percutaneous drainage performed. As a result, the patient's fever and c-reactive protein (CRP) subsequently improved. After six weeks of antibiotic therapy, an abdominal computed tomography scan revealed remains of the liver abscess as well as an ileus in the small bowel. Molds from the Mucor genus were cultured from repeated liver abscess drainage and an abscess wall biopsy confirmed hepatic mucormycosis. Along with administration of amphotericin-B deoxycholate for four weeks, we performed lobectomy for hepatic mucormycosis and small bowel resection for a suspected small bowel mucormycosis. After these operations, the patient received liposomal amphotericin B for three weeks and was then maintained with oral posaconazole for more than four weeks. Our case report suggests that hepatic mucormycosis should be considered when a hepatic abscess exhibits a retarded response to antibacterial agents, especially for patients with risk factors. In addition, because an isolated hepatic mucormycosis is infrequent, a thorough search for the extent of the disease is necessary before surgical resection.

Original languageEnglish
Pages (from-to)516-521
Number of pages6
JournalInfection and Chemotherapy
Volume44
Issue number6
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Mucormycosis
Liver Abscess
Acute Myeloid Leukemia
Drug Therapy
Liver
meropenem
Abscess
Drainage
Anti-Bacterial Agents
Mucor
Induction Chemotherapy
Ileus
Klebsiella pneumoniae
Ciprofloxacin
Fungi
Fever
Tomography
Biopsy
Proteins

Keywords

  • Acute myeloid leukemia
  • Chemotherapy
  • Mucormycosis
  • Small bowel

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Hepatic and Small Bowel Mucormycosis after Chemotherapy in a Patient with Acute Myeloid Leukemia : A Case Report and Literature Review. / Yang, Tae Un; Kim, Sun Hwa; Choi, Byeong Kwang; Lee, Soon Wook; Park, Joo Hee; Hong, Kyung Wook; Kim, In Sun; Seo, Yu Bin; Choi, Chul Won; Kim, Woo Joo.

In: Infection and Chemotherapy, Vol. 44, No. 6, 01.12.2012, p. 516-521.

Research output: Contribution to journalArticle

Yang, Tae Un ; Kim, Sun Hwa ; Choi, Byeong Kwang ; Lee, Soon Wook ; Park, Joo Hee ; Hong, Kyung Wook ; Kim, In Sun ; Seo, Yu Bin ; Choi, Chul Won ; Kim, Woo Joo. / Hepatic and Small Bowel Mucormycosis after Chemotherapy in a Patient with Acute Myeloid Leukemia : A Case Report and Literature Review. In: Infection and Chemotherapy. 2012 ; Vol. 44, No. 6. pp. 516-521.
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