Hepatic reduction of insulin-like growth factor (IGF)-I and IGF binding protein-3 that results from fasting is not attenuated in genetically obese rats

Kee Hyoung Lee, Jihui Zhang, Louis E. Underwood

Research output: Contribution to journalArticle

Abstract

Fasting or caloric restriction causes substantial reductions in serum IGF-I in normal weight humans and animals, and reductions of liver IGF-I and IGFBP-3 mRNAs in animals. Obese humans, however, have attenuated and delayed decrements in IGF-I in serum when subjected to caloric restriction. Obese Zucker rats show a clear tendency to preserve body protein during fasting. To determine whether obesity opposes the effects of fasting on IGF-I and IGFBP-3, and thereby contributes to preservation of lean tissue, we have examined the effect of 72 h of fasting on IGF-I and IGFBP-3 in lean and obese Zucker rats. We observe that between lean and obese animals, fasting for 72 h produces similar decrements in body weight, serum IGF-I, liver IGF-I mRNA, serum IGFBP-3 and liver IGFBP-3 mRNA. Our finding that the reduction of IGF-I and IGFBP-3 in liver that results from 72 h of fasting is not attenuated in obese Zucker rats raises the possibility that conservation of lean tissue in these animals during fasting is not related to the hepatic production of IGF-I and IGFBP-3.

Original languageEnglish
Pages (from-to)664-670
Number of pages7
JournalJournal of Nutritional Biochemistry
Volume13
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1

Fingerprint

Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Rats
Fasting
Liver
Zucker Rats
Animals
Caloric Restriction
Serum
Messenger RNA
Tissue
Tissue Preservation
Conservation
Obesity
Body Weight
Weights and Measures

Keywords

  • Fasting
  • IGF-I
  • IGFBP-3
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Hepatic reduction of insulin-like growth factor (IGF)-I and IGF binding protein-3 that results from fasting is not attenuated in genetically obese rats. / Lee, Kee Hyoung; Zhang, Jihui; Underwood, Louis E.

In: Journal of Nutritional Biochemistry, Vol. 13, No. 11, 01.11.2002, p. 664-670.

Research output: Contribution to journalArticle

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