Hepatokines as a link between obesity and cardiovascular diseases

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalDiabetes and Metabolism Journal
Volume39
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Selenoprotein P
Cardiovascular Diseases
Obesity
alpha-2-HS-Glycoprotein
Liver
Type 2 Diabetes Mellitus
Atherosclerosis
Proteins
fibroblast growth factor 21
Non-alcoholic Fatty Liver Disease

Keywords

  • Fetuin-A
  • Fibroblast growth factor 21
  • Hepatokines
  • Non-alcoholic fatty liver disease
  • Selenoprotein P

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Hepatokines as a link between obesity and cardiovascular diseases. / Yoo, Hye-Jin; Choi, Kyung Mook.

In: Diabetes and Metabolism Journal, Vol. 39, No. 1, 01.01.2015, p. 10-15.

Research output: Contribution to journalReview article

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