HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

Hoyeon Lee, Soojin Uhm, Jung Won Shin, Hyun Mi Jeon, Sun Dongbang, Hyo Sung Jung, Yun Cheol Na, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

Original languageEnglish
Pages (from-to)2695-2700
Number of pages6
JournalChemistry - An Asian Journal
Volume10
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Camptothecin
Drug delivery
Galactose
Pharmaceutical Preparations
Prodrugs

Keywords

  • anticancer drugs
  • camptothecin
  • cancer
  • drug delivery
  • galactose

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery. / Lee, Hoyeon; Uhm, Soojin; Shin, Jung Won; Jeon, Hyun Mi; Dongbang, Sun; Jung, Hyo Sung; Na, Yun Cheol; Kang, Chulhun; Kim, Jong Seung.

In: Chemistry - An Asian Journal, Vol. 10, No. 12, 01.12.2015, p. 2695-2700.

Research output: Contribution to journalArticle

Lee, H, Uhm, S, Shin, JW, Jeon, HM, Dongbang, S, Jung, HS, Na, YC, Kang, C & Kim, JS 2015, 'HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery', Chemistry - An Asian Journal, vol. 10, no. 12, pp. 2695-2700. https://doi.org/10.1002/asia.201500913
Lee, Hoyeon ; Uhm, Soojin ; Shin, Jung Won ; Jeon, Hyun Mi ; Dongbang, Sun ; Jung, Hyo Sung ; Na, Yun Cheol ; Kang, Chulhun ; Kim, Jong Seung. / HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery. In: Chemistry - An Asian Journal. 2015 ; Vol. 10, No. 12. pp. 2695-2700.
@article{eb169cdb0df447d09a9ff255ea9edd86,
title = "HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery",
abstract = "A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.",
keywords = "anticancer drugs, camptothecin, cancer, drug delivery, galactose",
author = "Hoyeon Lee and Soojin Uhm and Shin, {Jung Won} and Jeon, {Hyun Mi} and Sun Dongbang and Jung, {Hyo Sung} and Na, {Yun Cheol} and Chulhun Kang and Kim, {Jong Seung}",
year = "2015",
month = "12",
day = "1",
doi = "10.1002/asia.201500913",
language = "English",
volume = "10",
pages = "2695--2700",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

TY - JOUR

T1 - HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

AU - Lee, Hoyeon

AU - Uhm, Soojin

AU - Shin, Jung Won

AU - Jeon, Hyun Mi

AU - Dongbang, Sun

AU - Jung, Hyo Sung

AU - Na, Yun Cheol

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

AB - A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

KW - anticancer drugs

KW - camptothecin

KW - cancer

KW - drug delivery

KW - galactose

UR - http://www.scopus.com/inward/record.url?scp=84957010404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957010404&partnerID=8YFLogxK

U2 - 10.1002/asia.201500913

DO - 10.1002/asia.201500913

M3 - Article

VL - 10

SP - 2695

EP - 2700

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

SN - 1861-4728

IS - 12

ER -