HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

Hoyeon Lee, Soojin Uhm, Jung Won Shin, Hyun Mi Jeon, Sun Dongbang, Hyo Sung Jung, Yun Cheol Na, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

Original languageEnglish
Pages (from-to)2695-2700
Number of pages6
JournalChemistry - An Asian Journal
Volume10
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Keywords

  • anticancer drugs
  • camptothecin
  • cancer
  • drug delivery
  • galactose

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Lee, H., Uhm, S., Shin, J. W., Jeon, H. M., Dongbang, S., Jung, H. S., Na, Y. C., Kang, C., & Kim, J. S. (2015). HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery. Chemistry - An Asian Journal, 10(12), 2695-2700. https://doi.org/10.1002/asia.201500913