Abstract
A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
| Original language | English |
|---|---|
| Pages (from-to) | 151-154 |
| Number of pages | 4 |
| Journal | ACS Medicinal Chemistry Letters |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Feb 9 |
| Externally published | Yes |
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Keywords
- α-Galactosylceramide
- CD1d
- cytokine secretion
- noncovalent interaction
- selectivity
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d. / Kim, Yongju; Kim, Jonghoon; Oh, Keunhee; Lee, Dong Sup; Park, Seung Bum.
In: ACS Medicinal Chemistry Letters, Vol. 3, No. 2, 09.02.2012, p. 151-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d
AU - Kim, Yongju
AU - Kim, Jonghoon
AU - Oh, Keunhee
AU - Lee, Dong Sup
AU - Park, Seung Bum
PY - 2012/2/9
Y1 - 2012/2/9
N2 - A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
AB - A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
KW - α-Galactosylceramide
KW - CD1d
KW - cytokine secretion
KW - noncovalent interaction
KW - selectivity
UR - http://www.scopus.com/inward/record.url?scp=84863136172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863136172&partnerID=8YFLogxK
U2 - 10.1021/ml200278u
DO - 10.1021/ml200278u
M3 - Article
AN - SCOPUS:84863136172
VL - 3
SP - 151
EP - 154
JO - ACS Medicinal Chemistry Letters
JF - ACS Medicinal Chemistry Letters
SN - 1948-5875
IS - 2
ER -