Abstract
A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
Original language | English |
---|---|
Pages (from-to) | 151-154 |
Number of pages | 4 |
Journal | ACS Medicinal Chemistry Letters |
Volume | 3 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2012 Feb 9 |
Externally published | Yes |
Keywords
- CD1d
- cytokine secretion
- noncovalent interaction
- selectivity
- α-Galactosylceramide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry