Abstract
A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
| Original language | English |
|---|---|
| Pages (from-to) | 151-154 |
| Number of pages | 4 |
| Journal | ACS Medicinal Chemistry Letters |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Feb 9 |
| Externally published | Yes |
Keywords
- α-Galactosylceramide
- CD1d
- cytokine secretion
- noncovalent interaction
- selectivity
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Kim, Y., Kim, J., Oh, K., Lee, D. S., & Park, S. B. (2012). Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d. ACS Medicinal Chemistry Letters, 3(2), 151-154. https://doi.org/10.1021/ml200278u