Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d

Yongju Kim, Jonghoon Kim, Keunhee Oh, Dong Sup Lee, Seung Bum Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume3
Issue number2
DOIs
Publication statusPublished - 2012 Feb 9
Externally publishedYes

Fingerprint

Galactosylceramides
Sphingosine
Cytokines
Natural Killer T-Cells
T-cells
In Vitro Techniques

Keywords

  • α-Galactosylceramide
  • CD1d
  • cytokine secretion
  • noncovalent interaction
  • selectivity

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d. / Kim, Yongju; Kim, Jonghoon; Oh, Keunhee; Lee, Dong Sup; Park, Seung Bum.

In: ACS Medicinal Chemistry Letters, Vol. 3, No. 2, 09.02.2012, p. 151-154.

Research output: Contribution to journalArticle

Kim, Yongju ; Kim, Jonghoon ; Oh, Keunhee ; Lee, Dong Sup ; Park, Seung Bum. / Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d. In: ACS Medicinal Chemistry Letters. 2012 ; Vol. 3, No. 2. pp. 151-154.
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