Heterocyclic aromatic amine pesticide use and human cancer risk: Eesults from the U.S. Agricultural Health Study

Stella Koutras, Charles F. Lynch, Ma Xiaomei, Won Jin Lee, Jane A. Hoppin, Carol H. Christensen, Gabriella Andreotti, Laura Beane Freeman, Jennifer A. Rusiecki, Hon Lifang, Dale P. Sandler, Michael C.R. Alavanja

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Imazethapyr, a heterocyclic aromatic amine, is a widely used crop herbicide irst registered for use in the United States in 1989. We evaluated cancer incidence among imazethapyr-exposed pesticide applicators enrolled in the Agricultural Health Study (AHS). The AHS is a prospective cohort of 57,311 licensed pesticide applicators in the U.S., enrolled from 1993-1997. Among the 49,398 licensed pesticide applicators eligible for analysis, 20,646 applicators reported use of imazethapyr and 2,907 incident cancers developed through 2004. Imazethapyr exposure was classified by intensity-weighted lifetime exposure days calculated as [years of use × days per year × intensity level], Poisson regression analysis was used to evaluate the relationship between imazethapyr exposure and cancer incidence. We found significant trends in risk with increasing lifetime exposure for bladder cancer (p for trend 0.01) and colon cancer (p for trend 0.02). Rate ratios (RRs) were increased by 137% for bladder cancer and 78% for colon cancer when the highest exposed were compared to the nonexposed. The excess risk for colon cancer was limited to proximal cancers, (RR = 2.73, 95% confidence intervals 1.42, 5.25, p for trend 0,001). No association was observed for prostate, lung, rectum, kidney, oral, pancreas, lymphohematopoietic cancers or melanoma, these Indings provide new evidence that exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer. The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans.

Original languageEnglish
Pages (from-to)1206-1212
Number of pages7
JournalInternational Journal of Cancer
Volume124
Issue number5
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Pesticides
Amines
Colonic Neoplasms
Health
Urinary Bladder Neoplasms
Neoplasms
Incidence
Herbicides
Pancreatic Neoplasms
Rectum
imazethapyr
Prostate
Melanoma
Regression Analysis
Confidence Intervals
Kidney
Lung

Keywords

  • Bladder
  • Colon
  • Occupational exposures
  • Pesticides

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Koutras, S., Lynch, C. F., Xiaomei, M., Lee, W. J., Hoppin, J. A., Christensen, C. H., ... Alavanja, M. C. R. (2009). Heterocyclic aromatic amine pesticide use and human cancer risk: Eesults from the U.S. Agricultural Health Study. International Journal of Cancer, 124(5), 1206-1212. https://doi.org/10.1002/ijc.24020

Heterocyclic aromatic amine pesticide use and human cancer risk : Eesults from the U.S. Agricultural Health Study. / Koutras, Stella; Lynch, Charles F.; Xiaomei, Ma; Lee, Won Jin; Hoppin, Jane A.; Christensen, Carol H.; Andreotti, Gabriella; Freeman, Laura Beane; Rusiecki, Jennifer A.; Lifang, Hon; Sandler, Dale P.; Alavanja, Michael C.R.

In: International Journal of Cancer, Vol. 124, No. 5, 01.03.2009, p. 1206-1212.

Research output: Contribution to journalArticle

Koutras, S, Lynch, CF, Xiaomei, M, Lee, WJ, Hoppin, JA, Christensen, CH, Andreotti, G, Freeman, LB, Rusiecki, JA, Lifang, H, Sandler, DP & Alavanja, MCR 2009, 'Heterocyclic aromatic amine pesticide use and human cancer risk: Eesults from the U.S. Agricultural Health Study', International Journal of Cancer, vol. 124, no. 5, pp. 1206-1212. https://doi.org/10.1002/ijc.24020
Koutras, Stella ; Lynch, Charles F. ; Xiaomei, Ma ; Lee, Won Jin ; Hoppin, Jane A. ; Christensen, Carol H. ; Andreotti, Gabriella ; Freeman, Laura Beane ; Rusiecki, Jennifer A. ; Lifang, Hon ; Sandler, Dale P. ; Alavanja, Michael C.R. / Heterocyclic aromatic amine pesticide use and human cancer risk : Eesults from the U.S. Agricultural Health Study. In: International Journal of Cancer. 2009 ; Vol. 124, No. 5. pp. 1206-1212.
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