Heterogeneous organocatalysis for the asymmetric desymmetrization of meso-cyclic anhydrides using silica gel-supported bis-cinchona alkaloids

Hyun Sook Kim, Yu Mi Song, Jin Seok Choi, Jung Woon Yang, Hogyu Han

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The silica gel-supported bis-cinchona alkaloid 1a was prepared and found to be an efficient heterogeneous chiral organocatalyst with high catalytic activities, enantioselectivities (up to 92% ee), and recyclability for the asymmetric desymmetrization of meso-cyclic anhydrides with alcoholysis. Graphical Abstract

Original languageEnglish
Pages (from-to)12051-12057
Number of pages7
JournalTetrahedron
Volume60
Issue number52
DOIs
Publication statusPublished - 2004 Dec 20

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Cinchona Alkaloids
Anhydrides
Enantioselectivity
Silica Gel
Catalyst activity

Keywords

  • Asymmetric organocatalysis
  • Cinchona alkaloid
  • Cyclic anhydride
  • Desymmetrization
  • Heterogeneous chiral organocatalyst

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Heterogeneous organocatalysis for the asymmetric desymmetrization of meso-cyclic anhydrides using silica gel-supported bis-cinchona alkaloids. / Kim, Hyun Sook; Song, Yu Mi; Choi, Jin Seok; Yang, Jung Woon; Han, Hogyu.

In: Tetrahedron, Vol. 60, No. 52, 20.12.2004, p. 12051-12057.

Research output: Contribution to journalArticle

Kim, Hyun Sook ; Song, Yu Mi ; Choi, Jin Seok ; Yang, Jung Woon ; Han, Hogyu. / Heterogeneous organocatalysis for the asymmetric desymmetrization of meso-cyclic anhydrides using silica gel-supported bis-cinchona alkaloids. In: Tetrahedron. 2004 ; Vol. 60, No. 52. pp. 12051-12057.
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