Heterogeneous organocatalysis for the asymmetric desymmetrization of meso-cyclic anhydrides using silica gel-supported bis-cinchona alkaloids

Hyun Sook Kim, Yu Mi Song, Jin Seok Choi, Jung Woon Yang, Hogyu Han

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

The silica gel-supported bis-cinchona alkaloid 1a was prepared and found to be an efficient heterogeneous chiral organocatalyst with high catalytic activities, enantioselectivities (up to 92% ee), and recyclability for the asymmetric desymmetrization of meso-cyclic anhydrides with alcoholysis. Graphical Abstract

Original languageEnglish
Pages (from-to)12051-12057
Number of pages7
JournalTetrahedron
Volume60
Issue number52
DOIs
Publication statusPublished - 2004 Dec 20

Keywords

  • Asymmetric organocatalysis
  • Cinchona alkaloid
  • Cyclic anhydride
  • Desymmetrization
  • Heterogeneous chiral organocatalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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