Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

Eun Ji Kim, Jong Hyun Lee, Hyukjae Choi, Alban R. Pereira, Yeon Hee Ban, Young Ji Yoo, Eunji Kim, Je Won Park, David H. Sherman, William H. Gerwick, Yeo Joon Yoon

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40 Citations (Scopus)

Abstract

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

Original languageEnglish
Pages (from-to)5824-5827
Number of pages4
JournalOrganic Letters
Volume14
Issue number23
DOIs
Publication statusPublished - 2012 Dec 7
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Kim, E. J., Lee, J. H., Choi, H., Pereira, A. R., Ban, Y. H., Yoo, Y. J., Kim, E., Park, J. W., Sherman, D. H., Gerwick, W. H., & Yoon, Y. J. (2012). Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product. Organic Letters, 14(23), 5824-5827. https://doi.org/10.1021/ol302575h