Heteronuclear Gd- 99mTc complex of DTPA-bis(histidylamide) conjugate as a bimodal MR/SPECT imaging probe

Ji Ae Park, Jung Young Kim, Hee Kyung Kim, Wonho Lee, Sang Moo Lim, Yongmin Chang, Tae Jeong Kim, Kyeong Min Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The work describes the synthesis and in vivo application of heterotrimetallic complexes of the type {Gd(H 2O)[(M(H 2O)(CO) 3) 2(1)]} {1 = DTPA-bis(histidyl-amide); M = Re (3a); 99mTc (3b)} for dual modality MR/SPECT imaging. Here, the DTPA-bis(histidylamide) conjugate functions as a trinucleating chelate incorporating Gd in the DTPA core with Re or 99mTc in the pair of histidylamide side arms. The two complexes are chemically equivalent as revealed by HPLC, and their "cocktail mixture" (3a + 3b) has demonstrated itself to be essentially a single bimodal imaging probe. The present system has thus overcome the sensitivity difference problem between MRI and SPECT and paved the way for practical applications.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume3
Issue number4
DOIs
Publication statusPublished - 2012 Apr 12
Externally publishedYes

Keywords

  • cocktail mixture
  • dual modality
  • heterotrimetallic Gd-[ Tc] /[Re] complexes
  • imaging probe
  • MR/SPECT

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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