High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim, Sungwon Roh, Yujung Kim, Su Jung Yoon, Hae Kook Lee, Chang Su Han, Yong Ku Kim

    Research output: Contribution to journalArticlepeer-review

    68 Citations (Scopus)

    Abstract

    Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

    Original languageEnglish
    Pages (from-to)112-115
    Number of pages4
    JournalNeuroscience Letters
    Volume388
    Issue number2
    DOIs
    Publication statusPublished - 2005 Nov 11

    Keywords

    • BDNF
    • Dopamine
    • ELISA
    • Methamphetamine
    • Neurotoxicity

    ASJC Scopus subject areas

    • Neuroscience(all)

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