High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim, Sungwon Roh, Yujung Kim, Su Jung Yoon, Hae Kook Lee, Changsu Han, Yong Ku Kim

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalNeuroscience Letters
Volume388
Issue number2
DOIs
Publication statusPublished - 2005 Nov 11

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Methamphetamine
Brain-Derived Neurotrophic Factor
Addictive Behavior
Enzyme-Linked Immunosorbent Assay
Control Groups
Brain
Pharmaceutical Preparations

Keywords

  • BDNF
  • Dopamine
  • ELISA
  • Methamphetamine
  • Neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. / Kim, Dai Jin; Roh, Sungwon; Kim, Yujung; Yoon, Su Jung; Lee, Hae Kook; Han, Changsu; Kim, Yong Ku.

In: Neuroscience Letters, Vol. 388, No. 2, 11.11.2005, p. 112-115.

Research output: Contribution to journalArticle

Kim, Dai Jin ; Roh, Sungwon ; Kim, Yujung ; Yoon, Su Jung ; Lee, Hae Kook ; Han, Changsu ; Kim, Yong Ku. / High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. In: Neuroscience Letters. 2005 ; Vol. 388, No. 2. pp. 112-115.
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