High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Sun Young Ko; Chan Jeoung Park; Sang Hyuk Park; Young Uk Cho; Seongsoo Jang; Eul ju Seo; Nayoung Kim; Dae Young Kim; Kyung Nam Koh; Ho Joon Im; Jong Jin Seo; Hyun Sook Chi

doi:10.1016/j.leukres.2013.10.016

High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Sun Young Ko, Chan Jeoung Park, Sang Hyuk Park, Young Uk Cho, Seongsoo Jang, Eul ju Seo, Nayoung Kim, Dae Young Kim, Kyung Nam Koh, Ho Joon Im, Jong Jin Seo, Hyun Sook Chi

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

Original language	English
Pages (from-to)	65-70
Number of pages	6
Journal	Leukemia Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2013.10.016
Publication status	Published - 2014 Jan

Keywords

Acute lymphoblastic leukemia
Adult
CXCR4
Prognostic marker
Survival
VLA-4

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia. / Ko, Sun Young; Park, Chan Jeoung; Park, Sang Hyuk; Cho, Young Uk; Jang, Seongsoo; Seo, Eul ju; Kim, Nayoung; Kim, Dae Young; Koh, Kyung Nam; Im, Ho Joon; Seo, Jong Jin; Chi, Hyun Sook.

In: Leukemia Research, Vol. 38, No. 1, 01.2014, p. 65-70.

Research output: Contribution to journal › Article › peer-review

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abstract = "Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.",

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author = "Ko, {Sun Young} and Park, {Chan Jeoung} and Park, {Sang Hyuk} and Cho, {Young Uk} and Seongsoo Jang and Seo, {Eul ju} and Nayoung Kim and Kim, {Dae Young} and Koh, {Kyung Nam} and Im, {Ho Joon} and Seo, {Jong Jin} and Chi, {Hyun Sook}",

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AU - Seo, Eul ju

AU - Kim, Nayoung

AU - Kim, Dae Young

AU - Koh, Kyung Nam

AU - Im, Ho Joon

AU - Seo, Jong Jin

AU - Chi, Hyun Sook

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AB - Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

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KW - Survival

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