High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Sun Young Ko, Chan Jeoung Park, Sang Hyuk Park, Young Uk Cho, Seongsoo Jang, Eul ju Seo, Nayoung Kim, Dae Young Kim, Kyung Nam Koh, Ho Joon Im, Jong Jin Seo, Hyun Sook Chi

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

    Original languageEnglish
    Pages (from-to)65-70
    Number of pages6
    JournalLeukemia Research
    Volume38
    Issue number1
    DOIs
    Publication statusPublished - 2014 Jan

    Keywords

    • Acute lymphoblastic leukemia
    • Adult
    • CXCR4
    • Prognostic marker
    • Survival
    • VLA-4

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Cancer Research

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