Abstract
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.
Original language | English |
---|---|
Pages (from-to) | 65-70 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 38 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 Jan |
Keywords
- Acute lymphoblastic leukemia
- Adult
- CXCR4
- Prognostic marker
- Survival
- VLA-4
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research