High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Sun Young Ko; Chan Jeoung Park; Sang Hyuk Park; Young Uk Cho; Seongsoo Jang; Eul ju Seo; Nayoung Kim; Dae Young Kim; Kyung Nam Koh; Ho Joon Im; Jong Jin Seo; Hyun Sook Chi

doi:10.1016/j.leukres.2013.10.016

High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Sun Young Ko, Chan Jeoung Park, Sang Hyuk Park, Young Uk Cho, Seongsoo Jang, Eul ju Seo, Nayoung Kim, Dae Young Kim, Kyung Nam Koh, Ho Joon Im, Jong Jin Seo, Hyun Sook Chi

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

Original language	English
Pages (from-to)	65-70
Number of pages	6
Journal	Leukemia Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2013.10.016
Publication status	Published - 2014 Jan

Keywords

Acute lymphoblastic leukemia
Adult
CXCR4
Prognostic marker
Survival
VLA-4

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2013.10.016

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title = "High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia",

abstract = "Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.",

keywords = "Acute lymphoblastic leukemia, Adult, CXCR4, Prognostic marker, Survival, VLA-4",

author = "Ko, {Sun Young} and Park, {Chan Jeoung} and Park, {Sang Hyuk} and Cho, {Young Uk} and Seongsoo Jang and Seo, {Eul ju} and Nayoung Kim and Kim, {Dae Young} and Koh, {Kyung Nam} and Im, {Ho Joon} and Seo, {Jong Jin} and Chi, {Hyun Sook}",

note = "Funding Information: Role of the funding source. This study was supported by a grant from the Asan Institute for Life Sciences ( 2010-179 ). ",

year = "2014",

month = jan,

doi = "10.1016/j.leukres.2013.10.016",

language = "English",

volume = "38",

pages = "65--70",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "1",

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T1 - High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

AU - Ko, Sun Young

AU - Park, Chan Jeoung

AU - Park, Sang Hyuk

AU - Cho, Young Uk

AU - Jang, Seongsoo

AU - Seo, Eul ju

AU - Kim, Nayoung

AU - Kim, Dae Young

AU - Koh, Kyung Nam

AU - Im, Ho Joon

AU - Seo, Jong Jin

AU - Chi, Hyun Sook

N1 - Funding Information: Role of the funding source. This study was supported by a grant from the Asan Institute for Life Sciences ( 2010-179 ).

PY - 2014/1

Y1 - 2014/1

N2 - Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

AB - Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p= 0.01) and overall survival (p= 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p= 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.

KW - Acute lymphoblastic leukemia

KW - Adult

KW - CXCR4

KW - Prognostic marker

KW - Survival

KW - VLA-4

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DO - 10.1016/j.leukres.2013.10.016

M3 - Article

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VL - 38

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EP - 70

JO - Leukemia Research

JF - Leukemia Research

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ER -

High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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