High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

Hai Quyen Tran; Yoon Hee Chung; Eun Joo Shin; Won-Ki Kim; Jae Chul Lee; Ji Hoon Jeong; Myung Bok Wie; Choon Gon Jang; Kiyofumi Yamada; Toshitaka Nabeshima; Hyoung Chun Kim

doi:10.1016/j.jphs.2016.10.001

High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

Hai Quyen Tran, Yoon Hee Chung, Eun Joo Shin, Won-Ki Kim, Jae Chul Lee, Ji Hoon Jeong, Myung Bok Wie, Choon Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed.

Original language	English
Pages (from-to)	166-170
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	132
Issue number	2
DOIs	https://doi.org/10.1016/j.jphs.2016.10.001
Publication status	Published - 2016 Oct 1

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Keywords

Administration route
High-dose dextromethorphan
Myelinoid bodies with mitochondrial dysfunction

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Cite this

Tran, H. Q., Chung, Y. H., Shin, E. J., Kim, W-K., Lee, J. C., Jeong, J. H., Wie, M. B., Jang, C. G., Yamada, K., Nabeshima, T., & Kim, H. C. (2016). High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. Journal of Pharmacological Sciences, 132(2), 166-170. https://doi.org/10.1016/j.jphs.2016.10.001

High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. / Tran, Hai Quyen; Chung, Yoon Hee; Shin, Eun Joo; Kim, Won-Ki; Lee, Jae Chul; Jeong, Ji Hoon; Wie, Myung Bok; Jang, Choon Gon; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 132, No. 2, 01.10.2016, p. 166-170.

Research output: Contribution to journal › Article

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abstract = "Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed.",

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10.1016/j.jphs.2016.10.001