High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model

Young Hwii Ko, Yu Jeong Woo, Jin Wook Kim, Hoon Choi, Seok Ho Kang, Jeong Gu Lee, Je-Jong Kim, Hong Seok Park, Jun Cheon

Research output: Contribution to journalArticle

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Abstract

To evaluate the role of high-dose dietary zinc in the process of prostate malignancy, 60 Sprague-Dawley rats were randomly divided into four groups: tumor induction with carcinogen and hormone (group 1), oral zinc administration without tumor induction (group 2), oral zinc administration with tumor induction (group 3) and a control without zinc administration or tumor induction (group 4). Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group (P = 0.082), intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g-1, respectively. However, in group 3, zinc levels increased in both lobes to 59.3 and 12.1 μg g-1, respectively, comparable with that of group 4 (54.5 ± 14.6 and 14.1 ± 2.4 μg g-1). In spite of these increases in zinc concentration, the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 (53.3% and 46.7%) compared with group 1 (33.3% and 33.3%) in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4, zinc administration did induce prostate intraepithelial neoplasm in group 2 (46.7% and 40.0%). Thus, although high dietary zinc increased intraprostatic zinc concentrations, it promoted, instead of preventing, prostate intraepithelial neoplasm in a murine prostate malignancy induction model.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalAsian Journal of Andrology
Volume12
Issue number2
DOIs
Publication statusPublished - 2010 Mar 1

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Zinc
Prostate
Neoplasms
Carcinoma in Situ
Prostatic Neoplasms
Oral Administration
Zinc Sulfate
Drinking Water
Carcinogens
Sprague Dawley Rats
Hormones

Keywords

  • Experimental animal model
  • Prostatic cancer
  • Prostatic intraepithelial neoplasia
  • Zinc

ASJC Scopus subject areas

  • Urology

Cite this

High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model. / Ko, Young Hwii; Woo, Yu Jeong; Kim, Jin Wook; Choi, Hoon; Kang, Seok Ho; Lee, Jeong Gu; Kim, Je-Jong; Park, Hong Seok; Cheon, Jun.

In: Asian Journal of Andrology, Vol. 12, No. 2, 01.03.2010, p. 164-170.

Research output: Contribution to journalArticle

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abstract = "To evaluate the role of high-dose dietary zinc in the process of prostate malignancy, 60 Sprague-Dawley rats were randomly divided into four groups: tumor induction with carcinogen and hormone (group 1), oral zinc administration without tumor induction (group 2), oral zinc administration with tumor induction (group 3) and a control without zinc administration or tumor induction (group 4). Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group (P = 0.082), intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g-1, respectively. However, in group 3, zinc levels increased in both lobes to 59.3 and 12.1 μg g-1, respectively, comparable with that of group 4 (54.5 ± 14.6 and 14.1 ± 2.4 μg g-1). In spite of these increases in zinc concentration, the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 (53.3{\%} and 46.7{\%}) compared with group 1 (33.3{\%} and 33.3{\%}) in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4, zinc administration did induce prostate intraepithelial neoplasm in group 2 (46.7{\%} and 40.0{\%}). Thus, although high dietary zinc increased intraprostatic zinc concentrations, it promoted, instead of preventing, prostate intraepithelial neoplasm in a murine prostate malignancy induction model.",
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