High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model

Young Hwii Ko, Yu Jeong Woo, Jin Wook Kim, Hoon Choi, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim, Hong Seok Park, Jun Cheon

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

To evaluate the role of high-dose dietary zinc in the process of prostate malignancy, 60 Sprague-Dawley rats were randomly divided into four groups: tumor induction with carcinogen and hormone (group 1), oral zinc administration without tumor induction (group 2), oral zinc administration with tumor induction (group 3) and a control without zinc administration or tumor induction (group 4). Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group (P = 0.082), intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g-1, respectively. However, in group 3, zinc levels increased in both lobes to 59.3 and 12.1 μg g-1, respectively, comparable with that of group 4 (54.5 ± 14.6 and 14.1 ± 2.4 μg g-1). In spite of these increases in zinc concentration, the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 (53.3% and 46.7%) compared with group 1 (33.3% and 33.3%) in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4, zinc administration did induce prostate intraepithelial neoplasm in group 2 (46.7% and 40.0%). Thus, although high dietary zinc increased intraprostatic zinc concentrations, it promoted, instead of preventing, prostate intraepithelial neoplasm in a murine prostate malignancy induction model.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalAsian Journal of Andrology
Volume12
Issue number2
DOIs
Publication statusPublished - 2010 Mar

Keywords

  • Experimental animal model
  • Prostatic cancer
  • Prostatic intraepithelial neoplasia
  • Zinc

ASJC Scopus subject areas

  • Urology

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