High dose haemodialysis and haemodiafiltration parameters and the relationship with advanced vascular calcification

Sung Keun Park, Won Joong Kim, Hyun Jin Kim, Hae Won Kim, Beom Kim, Hong Joo Lee, So Young Lee, Yu Ho Lee, Dong Jin Kim, Kyung Hwan Jeong, Ju Young Moon, Sang Ho Lee, Shin Young Ahn, Gang Jee Ko, Jae Hong Ryoo, Dong Young Lee

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Background: Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). However, evidence is still insufficient about the association between dialysis parameters and VC. Thus, this study was to evaluate association of dialysis parameters with VC. Methods: We enrolled 297 ESRD patients undergoing MHD at six distinct centers in Korea. Study participants were categorized into 3 groups by the scoring system of abdominal aortic calcification based on lateral lumbar radiography (no VC group: 0, mild VC group: 1-7 and advanced VC group: 8-24). We compared the features of dialysis parameters according to the severity of VC. Multivariate logistic regression analysis was used to calculate adjusted odd ratios (ORs) and 95% confidence interval (CI) for mild and advanced VC in each haemodialysis parameter (adjusted OR [95% CI]). Results: Pooled Kt/V (spKt/V), equilibrated Kt/V (eKt/V), standard Kt/V (stdKt/V) and the proportion of haemodiafiltration were increased along with the severity of VC. Multivariate regression analysis indicated that advanced VC was positively associated with spKt/V (5.27 [1.51-18.41]), eKt/V (6.16 [1.45-26.10]), stdKt/V (10.67 [1.74-65.52]) and haemodiafiltration (3.27 [1.74 to 6.16]). Conclusion: High dose dialysis and haemodiafiltration were significantly associated with advanced VC.

Original languageEnglish
Article number86
JournalBMC Nephrology
Issue number1
Publication statusPublished - 2020 Mar 6


  • End-stage renal disease
  • Haemodialysis
  • Kt/V
  • Vascular calcification

ASJC Scopus subject areas

  • Nephrology

Cite this

Park, S. K., Kim, W. J., Kim, H. J., Kim, H. W., Kim, B., Lee, H. J., Lee, S. Y., Lee, Y. H., Kim, D. J., Jeong, K. H., Moon, J. Y., Lee, S. H., Ahn, S. Y., Ko, G. J., Ryoo, J. H., & Lee, D. Y. (2020). High dose haemodialysis and haemodiafiltration parameters and the relationship with advanced vascular calcification. BMC Nephrology, 21(1), [86]. https://doi.org/10.1186/s12882-020-01738-4