High free fatty acid level is associated with recurrent stroke in cardioembolic stroke patients

Jeong Yoon Choi, Ji Sun Kim, Ji Hyun Kim, Kyungmi Oh, Seong Beom Koh, Woo Keun Seo

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Abstract

Objective: To determine whether the plasma level of free fatty acid (FFA) could be associated with recurrent stroke in cardioembolic (CE) stroke patients. Methods: We analyzed data from 669 acute ischemic stroke patients and examined the association between FFA concentration and recurrent stroke in CE stroke patients compared with non-CE stroke patients. Results: The baseline plasma FFA concentration (mEq/L) was approximately 1.5-fold higher in CE stroke patients (1.01 6 0.63) than in non-CE stroke patients (0.72 6 0.51). Multivariate logistic analysis showed that an increased level of FFA was significantly associated with CE stroke (hazard ratio [HR] 2.124, confidence interval [CI] 1.492-3.024). During the mean follow-up period of 25.4 months, a total of 56 (8.4%) patients experienced a stroke recurrence. The recurrence rate did not differ between patients with CE (10.5%) and non-CE (8.0%) stroke (p 5 0.396). In CE stroke patients, an elevated baseline FFA concentration was independently associated with stroke recurrence (HR 2.711, CI 1.056-6.959). However, there was no association between FFA and stroke recurrence in non-CE stroke patients. Conclusion: In this retrospective registry-based observational study, CE stroke seemed to be associated with elevated plasma level of FFA. In addition, the present study suggested that an elevated FFA concentration could be a useful indicator for predicting recurrent stroke in CE stroke patients.

Original languageEnglish
Pages (from-to)1142-1148
Number of pages7
JournalNeurology
Volume82
Issue number13
DOIs
Publication statusPublished - 2014 Apr 1

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ASJC Scopus subject areas

  • Clinical Neurology

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