High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats

Sohee Moon, Mak Soon Lee, Sunyoon Jung, Bori Kang, Seog Young Kim, Seonyoung Park, Hye Yeon Son, Chong Tai Kim, Young Hee Jo, In-Hwan Kim, Young Soon Kim, Yangha Kim

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2 Citations (Scopus)

Abstract

Stress contributes to physiological changes such as weight loss and hormonal imbalances. The aim of the present study was to investigate antistress effects of high hydrostatic pressure extract of ginger (HPG) in immobilization-stressed rats. Male Sprague-Dawley rats (n = 24) were divided into three groups as follows: control (C), immobilization stress (2 h daily, for 2 weeks) (S), and immobilization stress (2 h daily, for 2 weeks) plus oral administration of HPG (150 mg/kg body weight/day) (S+G). Immobilization stress reduced the body weight gain and thymus weight by 50.2% and 31.3%, respectively, compared to the control group. The levels of serum aspartate transaminase, alanine transaminase, and corticosterone were significantly higher in the stress group, compared to the control group. Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. HPG administration also increased the body weight gain and thymus weight by 12.7% and 16.6%, respectively, compared to the stress group. Furthermore, the mRNA levels of Th, Dbh, phenylethanolamine-N-methyltransferase, and P450scc were elevated by the HPG treatment when compared to the stress group. These results suggest that HPG would have antistress effects partially via the reversal of stress-induced physiological changes and suppression of mRNA expression of genes related to corticosterone and catecholamine synthetic enzymes.

Original languageEnglish
Pages (from-to)864-872
Number of pages9
JournalJournal of Medicinal Food
Volume20
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

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Keywords

  • body weight gain
  • corticosterone
  • gene expression
  • thymus weight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Moon, S., Lee, M. S., Jung, S., Kang, B., Kim, S. Y., Park, S., Son, H. Y., Kim, C. T., Jo, Y. H., Kim, I-H., Kim, Y. S., & Kim, Y. (2017). High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats. Journal of Medicinal Food, 20(9), 864-872. https://doi.org/10.1089/jmf.2017.3955