High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity

Sunyoon Jung, Mak Soon Lee, Yoonjin Shin, Chong Tai Kim, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalPreventive Nutrition and Food Science
Volume20
Issue number4
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Panax
Hydrostatic Pressure
High Fat Diet
high fat diet
white adipose tissue
obesity
Obesity
inflammation
Inflammation
rats
extracts
gene expression
White Adipose Tissue
tumor necrosis factors
peroxisomes
lipids
leptin
adipocytes
interleukin-6
cytokines

Keywords

  • Gene expression
  • High hydrostatic pressure
  • High-fat diet
  • Inflammation
  • Red ginseng

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity. / Jung, Sunyoon; Lee, Mak Soon; Shin, Yoonjin; Kim, Chong Tai; Kim, In-Hwan; Kim, Yangha.

In: Preventive Nutrition and Food Science, Vol. 20, No. 4, 01.12.2015, p. 253-259.

Research output: Contribution to journalArticle

Jung, Sunyoon ; Lee, Mak Soon ; Shin, Yoonjin ; Kim, Chong Tai ; Kim, In-Hwan ; Kim, Yangha. / High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity. In: Preventive Nutrition and Food Science. 2015 ; Vol. 20, No. 4. pp. 253-259.
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