High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity

Sunyoon Jung, Mak Soon Lee, Yoonjin Shin, Chong Tai Kim, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalPreventive Nutrition and Food Science
Volume20
Issue number4
DOIs
Publication statusPublished - 2015 Dec 1

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Keywords

  • Gene expression
  • High hydrostatic pressure
  • High-fat diet
  • Inflammation
  • Red ginseng

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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