High insulin-like growth factor-1 in patients with bipolar i disorder: A trait marker?

Yong Ku Kim, Kyoung Sae Na, Jung A. Hwang, Ho Kyoung Yoon, Heon Jeong Lee, Sang Woo Hahn, Bun Hee Lee, Han Yong Jung

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives Neurotrophic factors exert substantial effects on the central nervous system. The present study investigates the roles of insulin-like growth factor-1 (IGF-1), β-nerve growth factor (β-NGF), and brain-derived neurotrophic factor (BDNF) in bipolar disorder. Methods Baseline levels of culture-stimulated IGF-1, β-NGF, and BDNF were compared in 116 patients with bipolar I disorder and 123 healthy controls. Neurotrophic factors were also compared in patients before and after 6 weeks of pharmacotherapy. A multivariate logistic regression analysis was used to investigate the influence of the neurotrophic factors analyzed in quartile form, in relation to confounding variables, such as age, sex, and body mass index. Results IGF-1 was significantly higher in patients (mean=514.57, SD=259.78) than in healthy controls (mean=316.82, SD=270.00, p<0.0001) at baseline. Furthermore, higher levels of IGF-1 substantially increased the risk for bipolar I disorder. IGF-1 level was not significantly changed at 6-weeks (mean=506.41, SD=313.66). No changes in BDNF or β-NGF-1 levels were found following the 6-week treatment period. IGF-1 and β-NGF were negatively correlated in healthy controls, but not in patients. Severity of manic symptoms was not associated with any of the neurotrophic factors. Limitations We did not measure cortisol, growth hormone, or IGF-1 receptors. This study is cross-sectional in design. Conclusions Elevated IGF-1 levels may be a trait marker for bipolar disorder. Further studies are needed to thoroughly investigate the role of IGF-1 in relation to other neuroendocrine factors and biological markers for bipolar disorder.

Original languageEnglish
Pages (from-to)738-743
Number of pages6
JournalJournal of Affective Disorders
Volume151
Issue number2
DOIs
Publication statusPublished - 2013 Nov

Keywords

  • Bipolar disorder
  • Brain-derived neurotrophic factor
  • Insulin-like growth factor-1
  • Nerve growth factor
  • Neurotrophin

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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