High intraocular pressure is associated with cardiometabolic risk factors in South Korean men

Korean National Health and Nutrition Examination Survey, 2008-2010

Y. H. Kim, S. W. Jung, G. E. Nam, K. Do Han, A. R. Bok, S. J. Baek, K. H. Cho, Y. S. Choi, S. M. Kim, S. Y. Ju, D. H. Kim

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

ObjectiveElevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.MethodsWe analyzed data on 4875 men who participated in the Korean National Health and Nutrition Examination Survey 2008-2010. We recorded the values for age, weight, height, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostasis model assessment of estimated insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), non-HDL-C (NHDL-C), and TG/HDL-C, as well as sociodemographic factors. IOP was measured using Goldmann applanation tonometry.ResultsWeight, BMI, WC, SBP, DBP, FBG, insulin, HOMA-IR, TC, LDL-C, TG, NHDL-C, TG/HDL-C, and the prevalence of MetS differed significantly among the three groups with IOP (P<0.05). Mean IOP was higher in subjects who were obese and had hypertension, diabetes mellitus, MetS, abdominal obesity, high TG, high FBG, or high BP compared with normal subjects (P<0.005). Analysis using Pearson's correlation coefficient showed that all cardiometabolic risk factors were significantly associated with IOP (P<0.005), with the exception of WC and HDL-C. A multivariate linear regression analysis showed that IOP was positively correlated with BMI, SBP, DBP, FBG, HOMA-IR, TC, LDL-C, TG, NHDL-C, and TG/HDL-C after adjusting for all covariates (all P<0.05).ConclusionsCardiometabolic risk factors, including the components of MetS, are associated with increased IOP.

Original languageEnglish
Pages (from-to)672-679
Number of pages8
JournalEye (Basingstoke)
Volume28
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Nutrition Surveys
Intraocular Pressure
Blood Pressure
HDL Cholesterol
Blood Glucose
Fasting
Waist Circumference
LDL Cholesterol
Insulin Resistance
Triglycerides
Body Mass Index
Homeostasis
Cholesterol
Nutrition
Health
Risk Factors
Metabolic Syndrome X
Insulin
Manometry
Glaucoma

ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

Cite this

High intraocular pressure is associated with cardiometabolic risk factors in South Korean men : Korean National Health and Nutrition Examination Survey, 2008-2010. / Kim, Y. H.; Jung, S. W.; Nam, G. E.; Do Han, K.; Bok, A. R.; Baek, S. J.; Cho, K. H.; Choi, Y. S.; Kim, S. M.; Ju, S. Y.; Kim, D. H.

In: Eye (Basingstoke), Vol. 28, No. 6, 01.01.2014, p. 672-679.

Research output: Contribution to journalReview article

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title = "High intraocular pressure is associated with cardiometabolic risk factors in South Korean men: Korean National Health and Nutrition Examination Survey, 2008-2010",
abstract = "ObjectiveElevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.MethodsWe analyzed data on 4875 men who participated in the Korean National Health and Nutrition Examination Survey 2008-2010. We recorded the values for age, weight, height, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostasis model assessment of estimated insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), non-HDL-C (NHDL-C), and TG/HDL-C, as well as sociodemographic factors. IOP was measured using Goldmann applanation tonometry.ResultsWeight, BMI, WC, SBP, DBP, FBG, insulin, HOMA-IR, TC, LDL-C, TG, NHDL-C, TG/HDL-C, and the prevalence of MetS differed significantly among the three groups with IOP (P<0.05). Mean IOP was higher in subjects who were obese and had hypertension, diabetes mellitus, MetS, abdominal obesity, high TG, high FBG, or high BP compared with normal subjects (P<0.005). Analysis using Pearson's correlation coefficient showed that all cardiometabolic risk factors were significantly associated with IOP (P<0.005), with the exception of WC and HDL-C. A multivariate linear regression analysis showed that IOP was positively correlated with BMI, SBP, DBP, FBG, HOMA-IR, TC, LDL-C, TG, NHDL-C, and TG/HDL-C after adjusting for all covariates (all P<0.05).ConclusionsCardiometabolic risk factors, including the components of MetS, are associated with increased IOP.",
author = "Kim, {Y. H.} and Jung, {S. W.} and Nam, {G. E.} and {Do Han}, K. and Bok, {A. R.} and Baek, {S. J.} and Cho, {K. H.} and Choi, {Y. S.} and Kim, {S. M.} and Ju, {S. Y.} and Kim, {D. H.}",
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T1 - High intraocular pressure is associated with cardiometabolic risk factors in South Korean men

T2 - Korean National Health and Nutrition Examination Survey, 2008-2010

AU - Kim, Y. H.

AU - Jung, S. W.

AU - Nam, G. E.

AU - Do Han, K.

AU - Bok, A. R.

AU - Baek, S. J.

AU - Cho, K. H.

AU - Choi, Y. S.

AU - Kim, S. M.

AU - Ju, S. Y.

AU - Kim, D. H.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - ObjectiveElevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.MethodsWe analyzed data on 4875 men who participated in the Korean National Health and Nutrition Examination Survey 2008-2010. We recorded the values for age, weight, height, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostasis model assessment of estimated insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), non-HDL-C (NHDL-C), and TG/HDL-C, as well as sociodemographic factors. IOP was measured using Goldmann applanation tonometry.ResultsWeight, BMI, WC, SBP, DBP, FBG, insulin, HOMA-IR, TC, LDL-C, TG, NHDL-C, TG/HDL-C, and the prevalence of MetS differed significantly among the three groups with IOP (P<0.05). Mean IOP was higher in subjects who were obese and had hypertension, diabetes mellitus, MetS, abdominal obesity, high TG, high FBG, or high BP compared with normal subjects (P<0.005). Analysis using Pearson's correlation coefficient showed that all cardiometabolic risk factors were significantly associated with IOP (P<0.005), with the exception of WC and HDL-C. A multivariate linear regression analysis showed that IOP was positively correlated with BMI, SBP, DBP, FBG, HOMA-IR, TC, LDL-C, TG, NHDL-C, and TG/HDL-C after adjusting for all covariates (all P<0.05).ConclusionsCardiometabolic risk factors, including the components of MetS, are associated with increased IOP.

AB - ObjectiveElevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.MethodsWe analyzed data on 4875 men who participated in the Korean National Health and Nutrition Examination Survey 2008-2010. We recorded the values for age, weight, height, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostasis model assessment of estimated insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), non-HDL-C (NHDL-C), and TG/HDL-C, as well as sociodemographic factors. IOP was measured using Goldmann applanation tonometry.ResultsWeight, BMI, WC, SBP, DBP, FBG, insulin, HOMA-IR, TC, LDL-C, TG, NHDL-C, TG/HDL-C, and the prevalence of MetS differed significantly among the three groups with IOP (P<0.05). Mean IOP was higher in subjects who were obese and had hypertension, diabetes mellitus, MetS, abdominal obesity, high TG, high FBG, or high BP compared with normal subjects (P<0.005). Analysis using Pearson's correlation coefficient showed that all cardiometabolic risk factors were significantly associated with IOP (P<0.005), with the exception of WC and HDL-C. A multivariate linear regression analysis showed that IOP was positively correlated with BMI, SBP, DBP, FBG, HOMA-IR, TC, LDL-C, TG, NHDL-C, and TG/HDL-C after adjusting for all covariates (all P<0.05).ConclusionsCardiometabolic risk factors, including the components of MetS, are associated with increased IOP.

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DO - 10.1038/eye.2014.43

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