High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs

Jeong Hwan Kim, Seong Woo Kang, Seung Wook Kim, Hyo Ihl Chang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH 2PO4 0.25%, MgSO4 0.05%, MnSO4 0.02%, and CaCl2 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.

Original languageEnglish
Pages (from-to)1743-1748
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume69
Issue number9
DOIs
Publication statusPublished - 2005

Keywords

  • Astaxanthin
  • Carotenoids
  • High-level production
  • Statistical experimental designs
  • Xanthophyllomyces dendrorhous

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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