High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether

Cheol Soo Yoon, Hyun Deok Park, Se Yoon Kim, Soo Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical dimethylether(scDME) at various reaction conditions (time and temperature). The monomer conversion increased to ca. 90% on increasing the reaction time to ihr. The molecular weight of the poly(L-lactide)(PLLA) also increased to ca. 160,000 g · mol-1 over the same period. Increasing reaction temperature from 118 to 135°C or reaction pressure from 280 to 520 bar resulted in increased monomer conversion and molecular weight. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical anti-solvent process without residual organic solvent.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalMacromolecular Symposia
Volume249-250
DOIs
Publication statusPublished - 2007 Aug 1

Keywords

  • DME
  • Microsphere
  • PLLA
  • Polymerization
  • Supercritical fluid

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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