High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010

Han Gil Cho; Jang Hoon Choi; Woon Ho Kim; Hae Kun Hong; Mi Hye Yoon; Eek Hoon Jho; Chun Kang; Young Hee Lim

doi:10.1007/s00705-012-1482-9

High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010

Han Gil Cho, Jang Hoon Choi, Woon Ho Kim, Hae Kun Hong, Mi Hye Yoon, Eek Hoon Jho, Chun Kang, Young Hee Lim

Department of Public Health Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.

Original language	English
Pages (from-to)	241-245
Number of pages	5
Journal	Archives of virology
Volume	158
Issue number	1
DOIs	https://doi.org/10.1007/s00705-012-1482-9
Publication status	Published - 2013

Keywords

Amantadine resistance
Influenza A virus
Phylogenetic analysis

ASJC Scopus subject areas

Virology

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10.1007/s00705-012-1482-9

Cite this

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title = "High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010",

abstract = "Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.",

keywords = "Amantadine resistance, Influenza A virus, Phylogenetic analysis",

author = "Cho, {Han Gil} and Choi, {Jang Hoon} and Kim, {Woon Ho} and Hong, {Hae Kun} and Yoon, {Mi Hye} and Jho, {Eek Hoon} and Chun Kang and Lim, {Young Hee}",

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AU - Cho, Han Gil

AU - Choi, Jang Hoon

AU - Kim, Woon Ho

AU - Hong, Hae Kun

AU - Yoon, Mi Hye

AU - Jho, Eek Hoon

AU - Kang, Chun

AU - Lim, Young Hee

PY - 2013

Y1 - 2013

N2 - Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.

AB - Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.

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KW - Influenza A virus

KW - Phylogenetic analysis

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High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010

Abstract

Keywords

ASJC Scopus subject areas

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