High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010

Han Gil Cho, Jang Hoon Choi, Woon Ho Kim, Hae Kun Hong, Mi Hye Yoon, Eek Hoon Jho, Chun Kang, Young Hee Lim

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Amantadine resistance among influenza A viruses was investigated in South Korea in 2005-2010. Of 308 influenza A viruses examined, 229 had the S31N substitution in the M2 protein. The frequency of amantadine resistance was 30 %, 100 %, and 76 % in influenza A/H1N1, pandemic A/H1N1 2009(A/H1N1pdm), and A/H3N2 subtypes, respectively. The amantadine-resistant influenza A/H1N1pdm and A/H3N2 viruses were circulating continuously from 2008 to 2009 and from 2005 to 2006, respectively. Amantadine resistance among influenza A viruses increased dramatically during the 5-year study period, and this has diminished the usefulness of this class of drugs.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalArchives of Virology
Issue number1
Publication statusPublished - 2013 Jan 1



  • Amantadine resistance
  • Influenza A virus
  • Phylogenetic analysis

ASJC Scopus subject areas

  • Virology

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