High-risk human papillomavirus infection in the prediction of poor treatment response and disease recurrence in patients with vulvovaginal condyloma

Yu Jin Koo, Yeon Sun Kim, Kyung Jin Min, Jin-Hwa Hong, Jae Kwan Lee

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3 Citations (Scopus)


Objective To determine the predictive factors for progression and recurrence of vulvovaginal condyloma (VVC), with a specific focus on high-risk HPV (HR-HPV) infections. Methods Retrospective data were collected from 48 patients who were diagnosed with VVC and treated with topical trichloroacetic acid application or laser therapy during 2003-2014 at a hospital in South Korea. The diagnoses were made based on the presence of exophytic condylomatous lesions as assessed by direct visual inspection regardless of whether a biopsy was performed. Results Overall, 18 patients (50.0% of those with a test result) were positive for HR-HPV. Three-quarters of the patients with a poor treatment response had abnormal cytologies, and abnormal cytology was a risk factor for a poor response (odds ratio, 4.33 [95% confidence interval, 1.05-17.84]). During a median follow-up of 24 months, VVC recurred in seven (14.6%) patients. A high viral load (more than 50 relative light units) of HR-HPV was significantly associated with recurrence (odds ratio, 7.42, 95% confidence interval, 1.19-46.18). Conclusion A high HR-HPV load is a risk factor for recurrence, but is not related to treatment response. A poor treatment response is more related to abnormal cytology than it is to viral load.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
Publication statusPublished - 2016 Jan 1



  • Condyloma
  • Genital wart
  • HPV infection

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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