High-risk human papillomavirus infection is associated with premature rupture of membranes

Geum Joon Cho, Kyung Jin Min, Hye Ri Hong, Suhng Wook Kim, Jin Hwa Hong, Jae Kwan Lee, Min Jeong Oh, Hai Joong Kim

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Background: Human papillomavirus (HPV) is known to be more prevalent in spontaneous abortions than in elective terminations of pregnancy. More recently, placental infection with HPV was shown to be associated with spontaneous preterm delivery. However, no study has evaluated the prevalence of HPV infection in pregnant Korean females and its association with adverse pregnancy outcomes.Methods: We conducted a cross-sectional study of 311 females who gave birth at Korea University Medical Center. Our sample included 45 preterm deliveries, 50 cases of premature rupture of the membranes (PROM), 21 preeclampsia cases, and 8 gestational diabetes mellitus (GDM) patients. We used the Hybrid Capture II system to detect high-risk (HR)-HPV infection at six weeks postpartum.Results: The prevalence of HR-HPV infection was 14.1%. Women with HR-HPV infection had a higher incidence of PROM than those without HR-HPV. HR-HPV infection was associated with an increased risk of PROM (OR, 2.380; 95% CI, 1.103-5.134). The prevalence of preterm delivery, preeclampsia, or GDM was not different between the two groups. Conclusions: We observed a high prevalence of HR-HPV infection in pregnant women. Moreover, HR-HPV infection was associated with a risk of PROM at term. Further studies are needed to evaluate mechanisms by which HR-HPV infection induces PROM.

Original languageEnglish
Article number173
JournalBMC Pregnancy and Childbirth
Publication statusPublished - 2013 Sep 6


  • Complication
  • Human papillomavirus
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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