High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas: a multicenter prospective study

Jin Young Yoon, Hyung Tae Kim, Sung Pil Hong, Hyun Gun Kim, Jin Oh Kim, Dong Hoon Yang, Dong Il Park, Seun Ja Park, Hyun Soo Kim, Bora Keum, Cheol Hee Park, Chang Soo Eun, Suck Ho Lee, Il Hyun Baek, Dong Kyung Chang, Tae Il Kim

Research output: Contribution to journalArticle

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Abstract

Background and Aims Although the malignant progression of serrated polyps has been clearly documented, the malignant potential of the traditional serrated adenoma (TSA) subtype has not been established. We compared the prevalence of metachronous polyps in surveillance colonoscopies between patients with TSA and those with conventional adenomas (CAs). Methods Four hundred twenty patients were diagnosed with TSAs by current diagnostic criteria at 10 tertiary care university hospitals in Korea from January 2003 to December 2005; 186 patients who received surveillance colonoscopy after removal of initial polyps were enrolled. During the same time period, 372 age- and sex-matched patients diagnosed with CAs were used as a control group. Results TSA patients had a significantly higher recurrence rate of colorectal polyps compared with CA patients (66.1% vs 43.5%, respectively). TSA patients had a greater number (3 vs 2) and larger size (8.6 ± 5.7 vs 6.3 ± 5.2 mm) of recurrent polyps compared with CA patients. TSA patients also had a higher rate of CA (54.8% vs 37.9%), serrated adenoma (14.0% vs. 0.8%), and hyperplastic polyp (33.3% vs. 13.7%) recurrence compared with CA patients. TSA patients had significantly greater odds of having a recurrent high-risk polyp than CA patients (odds ratio, 2.37; 95% confidence interval, 1.55-3.63). Conclusions In comparison with patients with CAs, patients with TSAs have a higher metachronous occurrence rate of all polyp subtypes including CAs, serrated adenomas, and hyperplastic polyps. Moreover, the presence of TSAs is an independent predictor of a high-risk polyp occurrence.

Original languageEnglish
Pages (from-to)1087-1093
Number of pages7
JournalGastrointestinal Endoscopy
Volume82
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1

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Polyps
Adenoma
Multicenter Studies
Prospective Studies
Colonoscopy
Recurrence
Tertiary Healthcare
Korea

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas : a multicenter prospective study. / Yoon, Jin Young; Kim, Hyung Tae; Hong, Sung Pil; Kim, Hyun Gun; Kim, Jin Oh; Yang, Dong Hoon; Park, Dong Il; Park, Seun Ja; Kim, Hyun Soo; Keum, Bora; Park, Cheol Hee; Eun, Chang Soo; Lee, Suck Ho; Baek, Il Hyun; Chang, Dong Kyung; Kim, Tae Il.

In: Gastrointestinal Endoscopy, Vol. 82, No. 6, 01.12.2015, p. 1087-1093.

Research output: Contribution to journalArticle

Yoon, JY, Kim, HT, Hong, SP, Kim, HG, Kim, JO, Yang, DH, Park, DI, Park, SJ, Kim, HS, Keum, B, Park, CH, Eun, CS, Lee, SH, Baek, IH, Chang, DK & Kim, TI 2015, 'High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas: a multicenter prospective study', Gastrointestinal Endoscopy, vol. 82, no. 6, pp. 1087-1093. https://doi.org/10.1016/j.gie.2015.05.016
Yoon, Jin Young ; Kim, Hyung Tae ; Hong, Sung Pil ; Kim, Hyun Gun ; Kim, Jin Oh ; Yang, Dong Hoon ; Park, Dong Il ; Park, Seun Ja ; Kim, Hyun Soo ; Keum, Bora ; Park, Cheol Hee ; Eun, Chang Soo ; Lee, Suck Ho ; Baek, Il Hyun ; Chang, Dong Kyung ; Kim, Tae Il. / High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas : a multicenter prospective study. In: Gastrointestinal Endoscopy. 2015 ; Vol. 82, No. 6. pp. 1087-1093.
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abstract = "Background and Aims Although the malignant progression of serrated polyps has been clearly documented, the malignant potential of the traditional serrated adenoma (TSA) subtype has not been established. We compared the prevalence of metachronous polyps in surveillance colonoscopies between patients with TSA and those with conventional adenomas (CAs). Methods Four hundred twenty patients were diagnosed with TSAs by current diagnostic criteria at 10 tertiary care university hospitals in Korea from January 2003 to December 2005; 186 patients who received surveillance colonoscopy after removal of initial polyps were enrolled. During the same time period, 372 age- and sex-matched patients diagnosed with CAs were used as a control group. Results TSA patients had a significantly higher recurrence rate of colorectal polyps compared with CA patients (66.1{\%} vs 43.5{\%}, respectively). TSA patients had a greater number (3 vs 2) and larger size (8.6 ± 5.7 vs 6.3 ± 5.2 mm) of recurrent polyps compared with CA patients. TSA patients also had a higher rate of CA (54.8{\%} vs 37.9{\%}), serrated adenoma (14.0{\%} vs. 0.8{\%}), and hyperplastic polyp (33.3{\%} vs. 13.7{\%}) recurrence compared with CA patients. TSA patients had significantly greater odds of having a recurrent high-risk polyp than CA patients (odds ratio, 2.37; 95{\%} confidence interval, 1.55-3.63). Conclusions In comparison with patients with CAs, patients with TSAs have a higher metachronous occurrence rate of all polyp subtypes including CAs, serrated adenomas, and hyperplastic polyps. Moreover, the presence of TSAs is an independent predictor of a high-risk polyp occurrence.",
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T1 - High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas

T2 - a multicenter prospective study

AU - Yoon, Jin Young

AU - Kim, Hyung Tae

AU - Hong, Sung Pil

AU - Kim, Hyun Gun

AU - Kim, Jin Oh

AU - Yang, Dong Hoon

AU - Park, Dong Il

AU - Park, Seun Ja

AU - Kim, Hyun Soo

AU - Keum, Bora

AU - Park, Cheol Hee

AU - Eun, Chang Soo

AU - Lee, Suck Ho

AU - Baek, Il Hyun

AU - Chang, Dong Kyung

AU - Kim, Tae Il

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background and Aims Although the malignant progression of serrated polyps has been clearly documented, the malignant potential of the traditional serrated adenoma (TSA) subtype has not been established. We compared the prevalence of metachronous polyps in surveillance colonoscopies between patients with TSA and those with conventional adenomas (CAs). Methods Four hundred twenty patients were diagnosed with TSAs by current diagnostic criteria at 10 tertiary care university hospitals in Korea from January 2003 to December 2005; 186 patients who received surveillance colonoscopy after removal of initial polyps were enrolled. During the same time period, 372 age- and sex-matched patients diagnosed with CAs were used as a control group. Results TSA patients had a significantly higher recurrence rate of colorectal polyps compared with CA patients (66.1% vs 43.5%, respectively). TSA patients had a greater number (3 vs 2) and larger size (8.6 ± 5.7 vs 6.3 ± 5.2 mm) of recurrent polyps compared with CA patients. TSA patients also had a higher rate of CA (54.8% vs 37.9%), serrated adenoma (14.0% vs. 0.8%), and hyperplastic polyp (33.3% vs. 13.7%) recurrence compared with CA patients. TSA patients had significantly greater odds of having a recurrent high-risk polyp than CA patients (odds ratio, 2.37; 95% confidence interval, 1.55-3.63). Conclusions In comparison with patients with CAs, patients with TSAs have a higher metachronous occurrence rate of all polyp subtypes including CAs, serrated adenomas, and hyperplastic polyps. Moreover, the presence of TSAs is an independent predictor of a high-risk polyp occurrence.

AB - Background and Aims Although the malignant progression of serrated polyps has been clearly documented, the malignant potential of the traditional serrated adenoma (TSA) subtype has not been established. We compared the prevalence of metachronous polyps in surveillance colonoscopies between patients with TSA and those with conventional adenomas (CAs). Methods Four hundred twenty patients were diagnosed with TSAs by current diagnostic criteria at 10 tertiary care university hospitals in Korea from January 2003 to December 2005; 186 patients who received surveillance colonoscopy after removal of initial polyps were enrolled. During the same time period, 372 age- and sex-matched patients diagnosed with CAs were used as a control group. Results TSA patients had a significantly higher recurrence rate of colorectal polyps compared with CA patients (66.1% vs 43.5%, respectively). TSA patients had a greater number (3 vs 2) and larger size (8.6 ± 5.7 vs 6.3 ± 5.2 mm) of recurrent polyps compared with CA patients. TSA patients also had a higher rate of CA (54.8% vs 37.9%), serrated adenoma (14.0% vs. 0.8%), and hyperplastic polyp (33.3% vs. 13.7%) recurrence compared with CA patients. TSA patients had significantly greater odds of having a recurrent high-risk polyp than CA patients (odds ratio, 2.37; 95% confidence interval, 1.55-3.63). Conclusions In comparison with patients with CAs, patients with TSAs have a higher metachronous occurrence rate of all polyp subtypes including CAs, serrated adenomas, and hyperplastic polyps. Moreover, the presence of TSAs is an independent predictor of a high-risk polyp occurrence.

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