High-sensitivity C-reactive protein in the low- and intermediate-Framingham risk score groups: Analysis with 18F-fluorodeoxyglucose positron emission tomography

Sae Jeong Yang, Sungeun Kim, Hae Yoon Choi, Tae Nyun Kim, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10%) and intermediate- (10%-20%) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalInternational Journal of Cardiology
Volume163
Issue number3
DOIs
Publication statusPublished - 2013 Mar 10

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
C-Reactive Protein
Blood Vessels
Inflammation
Carotid Intima-Media Thickness
Pulse Wave Analysis
Ankle
Body Mass Index
Arm
Atherosclerotic Plaques
LDL Cholesterol
HDL Cholesterol
Insulin Resistance
Cardiovascular Diseases
Regression Analysis

Keywords

  • Atherosclerosis
  • Framingham risk score
  • High-sensitivity C-reactive protein
  • Inflammation
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{fe3ad381cbdd4ac2af93537d7c14350e,
title = "High-sensitivity C-reactive protein in the low- and intermediate-Framingham risk score groups: Analysis with 18F-fluorodeoxyglucose positron emission tomography",
abstract = "Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10{\%}) and intermediate- (10{\%}-20{\%}) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).",
keywords = "Atherosclerosis, Framingham risk score, High-sensitivity C-reactive protein, Inflammation, Positron emission tomography",
author = "Yang, {Sae Jeong} and Sungeun Kim and Choi, {Hae Yoon} and Kim, {Tae Nyun} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Sei-Hyun Baik and Choi, {Dong Seop} and Choi, {Kyung Mook}",
year = "2013",
month = "3",
day = "10",
doi = "10.1016/j.ijcard.2011.06.054",
language = "English",
volume = "163",
pages = "277--281",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - High-sensitivity C-reactive protein in the low- and intermediate-Framingham risk score groups

T2 - Analysis with 18F-fluorodeoxyglucose positron emission tomography

AU - Yang, Sae Jeong

AU - Kim, Sungeun

AU - Choi, Hae Yoon

AU - Kim, Tae Nyun

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2013/3/10

Y1 - 2013/3/10

N2 - Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10%) and intermediate- (10%-20%) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).

AB - Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10%) and intermediate- (10%-20%) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).

KW - Atherosclerosis

KW - Framingham risk score

KW - High-sensitivity C-reactive protein

KW - Inflammation

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=84874531706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874531706&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2011.06.054

DO - 10.1016/j.ijcard.2011.06.054

M3 - Article

C2 - 21719129

AN - SCOPUS:84874531706

VL - 163

SP - 277

EP - 281

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -