High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging

Heejo Moon; Yuna Jung; Youngseo Kim; Byeong Wook Kim; Jin Gyu Choi; Na Hee Kim; Myung Sook Oh; Sungnam Park; B. Moon Kim; Dokyoung Kim

doi:10.1021/acs.orglett.9b00784

High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging

Heejo Moon, Yuna Jung, Youngseo Kim, Byeong Wook Kim, Jin Gyu Choi, Na Hee Kim, Myung Sook Oh, Sungnam Park, B. Moon Kim, Dokyoung Kim

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A new donor (D)-acceptor (A) type naphthalene-based oxazepine-containing fluorophore, OXN-1, is reported, which shows unusually high stability in various environments. Its photophysical properties and structural stabilities under harsh conditions are thoroughly examined. The high stability of OXN-1 is explained by quantum chemical calculations. Its exceptional bioimaging capabilities for cells with low cytotoxicity are verified. In addition, its deep tissue imaging ability with two-photon microscopy (TPM) is evaluated.

Original language	English
Pages (from-to)	3891-3894
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	11
DOIs	https://doi.org/10.1021/acs.orglett.9b00784
Publication status	Published - 2019 Jun 7

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging. / Moon, Heejo; Jung, Yuna; Kim, Youngseo; Kim, Byeong Wook; Choi, Jin Gyu; Kim, Na Hee; Oh, Myung Sook; Park, Sungnam; Kim, B. Moon; Kim, Dokyoung.

In: Organic Letters, Vol. 21, No. 11, 07.06.2019, p. 3891-3894.

Research output: Contribution to journal › Article › peer-review

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