High-throughput synthesis of nanoscale lipid vesicles for controlling size and size distribution in a contractionexpansion array microchannel

Jisun Lee, Myung Gwon Lee, Cheulhee Jung, Hyun Gyu Park, Je Kyun Park

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a new synthesis method of liposomes with tunable size as well as enhanced monodispersity of the size distribution and high throughput in a contraction-expansion array (CEA) microchannel. Lipid vesicles were generated in the CEA microchannel by injecting lipids in isopropyl alcohol as a sample flow and phosphate buffered saline as a buffer flow, leading to spontaneous formation of liposomes. Generated lipid vesicles from the CEA microchannel showed narrower size distribution than ones from the linear microchannel. The throughput of the lipid generation in the CEA microchannel was ten times higher than previous works.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages191-193
Number of pages3
Publication statusPublished - 2011 Dec 1
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

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Keywords

  • Contraction-expansion array microchannel
  • High-throughput
  • Liposome

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Lee, J., Lee, M. G., Jung, C., Park, H. G., & Park, J. K. (2011). High-throughput synthesis of nanoscale lipid vesicles for controlling size and size distribution in a contractionexpansion array microchannel. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 191-193). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).