High tibial osteotomy using polycaprolactone-tricalcium phosphate polymer wedge in a micro pig model

H. C. Lim, Ji Hoon Bae, Hae Ryong Song, S. H. Teoh, H. K. Kim, D. H. Kum

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Medial open-wedge high tibial osteotomy has been gaining popularity in recent years, but adequate supporting material is required in the osteotomy gap for early weight-bearing and rapid union. The purpose of this study was to investigate whether the implantation of a polycaprolactone-tricalcium phosphate composite scaffold wedge would enhance healing of the osteotomy in a micro pig model. We carried out open-wedge high tibial osteotomies in 12 micro pigs aged from 12 to 16 months. A scaffold wedge was inserted into six of the osteotomies while the other six were left open. Bone healing was evaluated after three and six months using plain radiographs, CT scans, measurement of the bone mineral density and histological examination. Complete bone union was obtained at six months in both groups. There was no collapse at the osteotomy site, loss of correction or failure of fixation in either group. Staining with haematoxylin and eosin demonstrated that there was infiltration of new bone tissue into the macropores and along the periphery of the implanted scaffold in the scaffold group. The CT scans and measurement of the bone mineral density showed that at six months specimens in the scaffold group had a higher bone mineral density than in the control group, although the implantation of the polycaprolactone- tricalcium phosphate composite scaffold wedge did not enhance healing of the osteotomy.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalJournal of Bone and Joint Surgery - Series B
Volume93 B
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'High tibial osteotomy using polycaprolactone-tricalcium phosphate polymer wedge in a micro pig model'. Together they form a unique fingerprint.

  • Cite this