High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer

Eojin Kim, Bokyung Ahn, Harim Oh, Yoo Jin Lee, Jeong Hyeon Lee, Youngseok Lee, Chul Hwan Kim, Yang Seok Chae, Joo Young Kim

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The Hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core components of the Hippo pathway, and their prognostic roles have not yet been studied in advanced gastric cancers (AGCs). A total of 318 surgically resected AGCs were retrieved. Immunolabelling for LATS1/2, YAP1 and TEAD4 was compared with clinicopathological factors including patients' survival. High expression of YAP1 and TEAD4 was identified in 108 (34.0%) and 131 (41.2%) cases, respectively, and 223 (70.1%) cases were negative for LATS1/2 expression. High YAP1 expression was significantly correlated with the presence of perineural invasion (p=0.032). High YAP1 and high TEAD4 expressions were significantly associated with poor overall survival (p<0.001 and p=0.003, respectively), and negative LATS1/2 expression was also associated with poor overall survival (p=0.002). Combined expression of YAP1 high LATS1/2 neg showed the worst overall survival (p<0.001). Expression of YAP1 high (HR=2.938; 95% CI 1.726–4.998; p<0.001), LATS1/2 neg (HR=0.371; 95% CI 0.181–0.758; p=0.007), and combined YAP1 high LATS1/2 neg (HR=13.785; 95% CI 3.245–58.554; p<0.001) were independent poor prognostic factors of AGC patients. Combined or individual expression of YAP1, LATS1/2, and TEAD4 can be used as prognostic markers of AGC patients.

Original languageEnglish
Publication statusPublished - 2019 Jan 1



  • Advanced gastric cancer
  • hippo pathway
  • LATS1/2
  • prognosis
  • TEAD4
  • YAP1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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