Higher hemoglobin level is associated with subtle declines in renal function and presence of cardiorenal risk factors in early CKD stages

Se Won Oh, Seon Ha Baek, Yong Chul Kim, Ho Suk Goo, Ho Jun Chin, Ki Young Na, Dong Wan Chae, Suhnggwon Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background.Patients with advanced renal dysfunction have comorbidities, including anemia, as a consequence of reduced production of erythropoietin. However, little is known about the renal response to early decreases in estimated glomerular filtration rate (eGFR) before the onset of anemia. We therefore investigated the hemoglobin concentration across subtle declines in renal function stratified by cardiorenal risk factors, in subjects with eGFR ≥50 mL/min/1.73 m 2. Methods.Based on the data from routine health checkups in tertiary university hospitals during the last 15 years, 145865 adult subjects were identified. Results.Hemoglobin levels among eGFR Groups 2-6 (50 ≤ eGFR < 100 mL/min/1.73m 2) were significantly higher compared to eGFR group ≥100 mL/min/1.73m 2 (P < 0.001), and the highest level of mean hemoglobin was seen at eGFR 50-59 mL/min/1.73m 2. The mean hemoglobin level of subjects with eGFR 50-59 mL/min/1.73m 2 and eGFR ≥ 100 mL/min/1.73m 2 were 13.36 [95% confidence interval (CI): 13.33-13.40] g/dL versus 12.92 (95% CI: 12.88-12.95) g/dL in women (P < 0.001); in men, 15.60 (95% CI: 15.57-15.63) g/dL versus 15.15 (95% CI: 15.11-15.18) g/dL (P < 0.001). Among each eGFR group, hemoglobin levels were higher in subjects with hypertension (P < 0.001 in both genders), diabetes mellitus (P < 0.001 in both genders) and components of MS (P < 0.003 in both genders) compared to subjects without these conditions. Conclusion.Hemoglobin concentration may be slightly higher across subtle declines in renal function and the presence of cardiorenal risk factors in early CKD stages.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalNephrology Dialysis Transplantation
Volume27
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

Fingerprint

Glomerular Filtration Rate
Hemoglobins
Kidney
Confidence Intervals
Anemia
Erythropoietin
Tertiary Care Centers
Comorbidity
Diabetes Mellitus
Hypertension
Health

Keywords

  • cardio renal risk factor
  • glomerular filtration rate
  • hemoglobin
  • renal response

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Higher hemoglobin level is associated with subtle declines in renal function and presence of cardiorenal risk factors in early CKD stages. / Oh, Se Won; Baek, Seon Ha; Kim, Yong Chul; Goo, Ho Suk; Chin, Ho Jun; Na, Ki Young; Chae, Dong Wan; Kim, Suhnggwon.

In: Nephrology Dialysis Transplantation, Vol. 27, No. 1, 01.01.2012, p. 267-275.

Research output: Contribution to journalArticle

Oh, Se Won ; Baek, Seon Ha ; Kim, Yong Chul ; Goo, Ho Suk ; Chin, Ho Jun ; Na, Ki Young ; Chae, Dong Wan ; Kim, Suhnggwon. / Higher hemoglobin level is associated with subtle declines in renal function and presence of cardiorenal risk factors in early CKD stages. In: Nephrology Dialysis Transplantation. 2012 ; Vol. 27, No. 1. pp. 267-275.
@article{28c7844cea6a47459a9c89146557d174,
title = "Higher hemoglobin level is associated with subtle declines in renal function and presence of cardiorenal risk factors in early CKD stages",
abstract = "Background.Patients with advanced renal dysfunction have comorbidities, including anemia, as a consequence of reduced production of erythropoietin. However, little is known about the renal response to early decreases in estimated glomerular filtration rate (eGFR) before the onset of anemia. We therefore investigated the hemoglobin concentration across subtle declines in renal function stratified by cardiorenal risk factors, in subjects with eGFR ≥50 mL/min/1.73 m 2. Methods.Based on the data from routine health checkups in tertiary university hospitals during the last 15 years, 145865 adult subjects were identified. Results.Hemoglobin levels among eGFR Groups 2-6 (50 ≤ eGFR < 100 mL/min/1.73m 2) were significantly higher compared to eGFR group ≥100 mL/min/1.73m 2 (P < 0.001), and the highest level of mean hemoglobin was seen at eGFR 50-59 mL/min/1.73m 2. The mean hemoglobin level of subjects with eGFR 50-59 mL/min/1.73m 2 and eGFR ≥ 100 mL/min/1.73m 2 were 13.36 [95{\%} confidence interval (CI): 13.33-13.40] g/dL versus 12.92 (95{\%} CI: 12.88-12.95) g/dL in women (P < 0.001); in men, 15.60 (95{\%} CI: 15.57-15.63) g/dL versus 15.15 (95{\%} CI: 15.11-15.18) g/dL (P < 0.001). Among each eGFR group, hemoglobin levels were higher in subjects with hypertension (P < 0.001 in both genders), diabetes mellitus (P < 0.001 in both genders) and components of MS (P < 0.003 in both genders) compared to subjects without these conditions. Conclusion.Hemoglobin concentration may be slightly higher across subtle declines in renal function and the presence of cardiorenal risk factors in early CKD stages.",
keywords = "cardio renal risk factor, glomerular filtration rate, hemoglobin, renal response",
author = "Oh, {Se Won} and Baek, {Seon Ha} and Kim, {Yong Chul} and Goo, {Ho Suk} and Chin, {Ho Jun} and Na, {Ki Young} and Chae, {Dong Wan} and Suhnggwon Kim",
year = "2012",
month = "1",
day = "1",
doi = "10.1093/ndt/gfr296",
language = "English",
volume = "27",
pages = "267--275",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Higher hemoglobin level is associated with subtle declines in renal function and presence of cardiorenal risk factors in early CKD stages

AU - Oh, Se Won

AU - Baek, Seon Ha

AU - Kim, Yong Chul

AU - Goo, Ho Suk

AU - Chin, Ho Jun

AU - Na, Ki Young

AU - Chae, Dong Wan

AU - Kim, Suhnggwon

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background.Patients with advanced renal dysfunction have comorbidities, including anemia, as a consequence of reduced production of erythropoietin. However, little is known about the renal response to early decreases in estimated glomerular filtration rate (eGFR) before the onset of anemia. We therefore investigated the hemoglobin concentration across subtle declines in renal function stratified by cardiorenal risk factors, in subjects with eGFR ≥50 mL/min/1.73 m 2. Methods.Based on the data from routine health checkups in tertiary university hospitals during the last 15 years, 145865 adult subjects were identified. Results.Hemoglobin levels among eGFR Groups 2-6 (50 ≤ eGFR < 100 mL/min/1.73m 2) were significantly higher compared to eGFR group ≥100 mL/min/1.73m 2 (P < 0.001), and the highest level of mean hemoglobin was seen at eGFR 50-59 mL/min/1.73m 2. The mean hemoglobin level of subjects with eGFR 50-59 mL/min/1.73m 2 and eGFR ≥ 100 mL/min/1.73m 2 were 13.36 [95% confidence interval (CI): 13.33-13.40] g/dL versus 12.92 (95% CI: 12.88-12.95) g/dL in women (P < 0.001); in men, 15.60 (95% CI: 15.57-15.63) g/dL versus 15.15 (95% CI: 15.11-15.18) g/dL (P < 0.001). Among each eGFR group, hemoglobin levels were higher in subjects with hypertension (P < 0.001 in both genders), diabetes mellitus (P < 0.001 in both genders) and components of MS (P < 0.003 in both genders) compared to subjects without these conditions. Conclusion.Hemoglobin concentration may be slightly higher across subtle declines in renal function and the presence of cardiorenal risk factors in early CKD stages.

AB - Background.Patients with advanced renal dysfunction have comorbidities, including anemia, as a consequence of reduced production of erythropoietin. However, little is known about the renal response to early decreases in estimated glomerular filtration rate (eGFR) before the onset of anemia. We therefore investigated the hemoglobin concentration across subtle declines in renal function stratified by cardiorenal risk factors, in subjects with eGFR ≥50 mL/min/1.73 m 2. Methods.Based on the data from routine health checkups in tertiary university hospitals during the last 15 years, 145865 adult subjects were identified. Results.Hemoglobin levels among eGFR Groups 2-6 (50 ≤ eGFR < 100 mL/min/1.73m 2) were significantly higher compared to eGFR group ≥100 mL/min/1.73m 2 (P < 0.001), and the highest level of mean hemoglobin was seen at eGFR 50-59 mL/min/1.73m 2. The mean hemoglobin level of subjects with eGFR 50-59 mL/min/1.73m 2 and eGFR ≥ 100 mL/min/1.73m 2 were 13.36 [95% confidence interval (CI): 13.33-13.40] g/dL versus 12.92 (95% CI: 12.88-12.95) g/dL in women (P < 0.001); in men, 15.60 (95% CI: 15.57-15.63) g/dL versus 15.15 (95% CI: 15.11-15.18) g/dL (P < 0.001). Among each eGFR group, hemoglobin levels were higher in subjects with hypertension (P < 0.001 in both genders), diabetes mellitus (P < 0.001 in both genders) and components of MS (P < 0.003 in both genders) compared to subjects without these conditions. Conclusion.Hemoglobin concentration may be slightly higher across subtle declines in renal function and the presence of cardiorenal risk factors in early CKD stages.

KW - cardio renal risk factor

KW - glomerular filtration rate

KW - hemoglobin

KW - renal response

UR - http://www.scopus.com/inward/record.url?scp=84863031541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863031541&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfr296

DO - 10.1093/ndt/gfr296

M3 - Article

VL - 27

SP - 267

EP - 275

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 1

ER -