Higher levels of serum triglyceride and dietary carbohydrate intake are associated with smaller LDL particle size in healthy Korean women

Oh Yoen Kim, Hye Kyung Chung, Min-Jeong Shin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: 269.7Å, n = 44) and LDL phenotype B (mean size: 248.2Å, n = 13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r = -0.732, P < 0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En) and serum triglyceride levels were the primary factors influencing LDL particle size (P < 0.001, R2 = 0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalNutrition Research and Practice
Volume6
Issue number2
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Dietary Carbohydrates
carbohydrate intake
dietary carbohydrate
low density lipoprotein
LDL Lipoproteins
Particle Size
particle size
Triglycerides
triacylglycerols
Serum
Phenotype
phenotype
Apolipoproteins B
high density lipoprotein cholesterol
HDL Cholesterol
Cholesterol
Carbohydrates
cholesterol
apolipoprotein B
food frequency questionnaires

Keywords

  • Dietary carbohydrate
  • LDL particle size
  • LDL phenotype
  • Triglyceride

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Food Science

Cite this

Higher levels of serum triglyceride and dietary carbohydrate intake are associated with smaller LDL particle size in healthy Korean women. / Kim, Oh Yoen; Chung, Hye Kyung; Shin, Min-Jeong.

In: Nutrition Research and Practice, Vol. 6, No. 2, 01.04.2012, p. 120-125.

Research output: Contribution to journalArticle

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