TY - JOUR
T1 - Highly biocompatible amphiphilic perylenediimide derivative for bioimaging
AU - Park, Jin Kyung
AU - Kim, Ran Hee
AU - Prabhakaran, Prem
AU - Kim, Sehoon
AU - Lee, Kwang Sup
N1 - Funding Information:
This work was supported by the Active Polymer Center for Patterned Integration (ERC R 11-2007-050-01002-0) of the National Research Foundation of Korea and by the Hannam University funding (Kyobi 2015).
Publisher Copyright:
© 2016 Optical Society of America.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]- 1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging.
AB - We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]- 1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging.
UR - http://www.scopus.com/inward/record.url?scp=84975764659&partnerID=8YFLogxK
U2 - 10.1364/OME.6.001420
DO - 10.1364/OME.6.001420
M3 - Article
AN - SCOPUS:84975764659
SN - 2159-3930
VL - 6
SP - 1420
EP - 1428
JO - Optical Materials Express
JF - Optical Materials Express
IS - 5
ER -