Highly biocompatible amphiphilic perylenediimide derivative for bioimaging

Jin Kyung Park, Ran Hee Kim, Prem Prabhakaran, Sehoon Kim, Kwang Sup Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]- 1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging.

Original languageEnglish
Pages (from-to)1420-1428
Number of pages9
JournalOptical Materials Express
Volume6
Issue number5
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

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