Highly biocompatible amphiphilic perylenediimide derivative for bioimaging

Jin Kyung Park, Ran Hee Kim, Prem Prabhakaran, Sehoon Kim, Kwang Sup Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]- 1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging.

Original languageEnglish
Pages (from-to)1420-1428
Number of pages9
JournalOptical Materials Express
Volume6
Issue number5
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Fingerprint

Glycols
Derivatives
Coloring Agents
Dyes
Cells
Biocompatibility
Substitution reactions
Fluorescence
Perylene
Methyl Ethers
Molecules
Ethylene Glycol
Fluorophores
perylenediimide
Ethylene glycol
Liver
Ethers
Imaging techniques

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Highly biocompatible amphiphilic perylenediimide derivative for bioimaging. / Park, Jin Kyung; Kim, Ran Hee; Prabhakaran, Prem; Kim, Sehoon; Lee, Kwang Sup.

In: Optical Materials Express, Vol. 6, No. 5, 01.05.2016, p. 1420-1428.

Research output: Contribution to journalArticle

Park, Jin Kyung ; Kim, Ran Hee ; Prabhakaran, Prem ; Kim, Sehoon ; Lee, Kwang Sup. / Highly biocompatible amphiphilic perylenediimide derivative for bioimaging. In: Optical Materials Express. 2016 ; Vol. 6, No. 5. pp. 1420-1428.
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