We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]- 1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials