Highly Efficient Aggregation-Induced Red-Emissive Organic Thermally Activated Delayed Fluorescence Materials with Prolonged Fluorescence Lifetime for Time-Resolved Luminescence Bioimaging

Sujie Qi, Sangin Kim, Van Nghia Nguyen, Youngmee Kim, Guangle Niu, Gyoungmi Kim, Sung Jin Kim, Sungnam Park, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Organic thermally activated delayed fluorescence (TADF) materials are emerging as potential candidates for time-resolved fluorescence imaging in biological systems. However, the development of purely organic TADF materials with bright aggregated-state emissions in the red/near-infrared (NIR) region remains challenging. Here, we report three donor-acceptor-type TADF molecules as promising candidates for time-resolved fluorescence imaging, which are engineered by direct connection of electron-donating moieties (phenoxazine or phenothiazine) and an electron-acceptor 1,8-naphthalimide (NI). Theoretically and experimentally, we elucidate that three TADF materials possessed remarkably small ΔEST to promote the occurrence of reverse intersystem crossing (RISC). Moreover, they all exhibit aggregation-induced red emissions and long delayed fluorescence lifetimes without the influence of molecular oxygen. More importantly, these long-lived and biocompatible TADF materials, especially the phenoxazine-substituted NI fluorophores, show great potential for high-contrast fluorescence lifetime imaging in living cells. This study provides further a molecular design strategy for purely organic TADF materials and expands the versatile biological application of long-lived fluorescence research in time-resolved luminescence imaging.

Original languageEnglish
Pages (from-to)51293-51301
Number of pages9
JournalACS Applied Materials and Interfaces
Volume12
Issue number46
DOIs
Publication statusPublished - 2020 Nov 18

Keywords

  • aggregation-induced emission
  • fluorescence imaging
  • red emission
  • thermally activated delayed fluorescence (TADF)
  • time-resolved luminescence imaging

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint

Dive into the research topics of 'Highly Efficient Aggregation-Induced Red-Emissive Organic Thermally Activated Delayed Fluorescence Materials with Prolonged Fluorescence Lifetime for Time-Resolved Luminescence Bioimaging'. Together they form a unique fingerprint.

Cite this